{"id":"W4293077339","doi":"10.20944/preprints202206.0125.v1","title":"Post-Transcriptional Effects of miRNAs on <em>PCSK7</em> Expression and Function: miR-125a-5p, miR-143-3p and miR-409-3p as Negative Regulators","year":2022,"lang":"en","type":"preprint","venue":"Preprints.org","topic":"RNA Research and Splicing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Montreal Clinical Research Institute","funders":"Canadian Institutes of Health Research","keywords":"microRNA; Luciferase; Biology; Untranslated region; Three prime untranslated region; Regulation of gene expression; Western blot; Messenger RNA; Transfection; Molecular biology; Gene expression; Function (biology); Cell biology; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002470359,0.0003950062,0.0003716314,0.0002613619,0.000202686,0.000516741,0.00016657,0.0002100587,0.0008907693],"category_scores_gemma":[0.0003020462,0.000199419,0.0004022875,0.0001731214,0.0003386355,0.0002402875,0.0002263038,0.0004780668,0.0004781272],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004283532,"about_ca_system_score_gemma":0.0003620302,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007559723,"about_ca_topic_score_gemma":0.0006528317,"domain_scores_codex":[0.9997404,0.0000289557,0.00002550627,0.00008102454,0.00008334188,0.00004074663],"domain_scores_gemma":[0.9998505,0.0000322283,0.00004383396,0.00001356931,0.0000350686,0.00002471143],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002141987,0.00001620428,0.0006444805,0.00005674006,0.00001028679,0.00007268662,0.00003261818,0.0001456317,0.9956797,0.0002570431,0.00006651075,0.002803832],"study_design_scores_gemma":[0.00001109018,0.00007251348,0.008244059,0.000004585695,0.000026519,0.0001692187,0.00002516508,0.002137698,0.9870726,0.0000971155,0.002133152,0.000006317012],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9802349,0.00434205,0.01060004,0.0001484793,0.00005802416,0.00004793182,0.0008459339,0.0002846147,0.003437928],"genre_scores_gemma":[0.9885136,0.001057614,0.005868137,0.00008240598,0.00001386983,0.00006273925,0.0008383835,0.0000614595,0.0035017],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008907693,"threshold_uncertainty_score":0.003107905,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02563029417855983,"score_gpt":0.2946366788966298,"score_spread":0.2690063847180699,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}