{"id":"W4293094498","doi":"10.1200/jco.22.00364","title":"Circulating Tumor DNA Identifies Diverse Landscape of Acquired Resistance to Anti–Epidermal Growth Factor Receptor Therapy in Metastatic Colorectal Cancer","year":2022,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":67,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University of Ottawa; Ottawa Hospital; Queen's University; University of British Columbia","funders":"BC Cancer Foundation; Michael Smith Health Research BC; Terry Fox Research Institute; AstraZeneca","keywords":"Medicine; KRAS; Neuroblastoma RAS viral oncogene homolog; Colorectal cancer; Epidermal growth factor receptor; Internal medicine; Panitumumab; Oncology; Targeted therapy; Cancer research; Cetuximab; EGFR inhibitors; Cancer","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002578867,0.0001792138,0.0003286222,0.000449652,0.0001227827,0.0003835954,0.0001394725,0.0002127824,0.001248278],"category_scores_gemma":[0.0008019529,0.0001189957,0.0001017096,0.0003056862,0.0001648446,0.0002253835,0.0001640609,0.0002392001,0.0001364858],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000298817,"about_ca_system_score_gemma":0.0001401698,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006332995,"about_ca_topic_score_gemma":0.001499486,"domain_scores_codex":[0.9998146,0.0000355021,0.0000141217,0.00005881911,0.00005228817,0.00002479763],"domain_scores_gemma":[0.9995547,0.0001008155,0.0001919718,0.00002192457,0.00005235021,0.00007832181],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.004818923,0.0001761351,0.7833837,0.0001523805,0.0001248198,0.0004795873,0.0001231622,0.0005287027,0.1483934,0.0001020611,0.0005512801,0.06116591],"study_design_scores_gemma":[0.0001223177,0.001889259,0.9765816,0.0000148109,0.00008499117,0.002354824,0.00011691,0.001706974,0.01570181,0.0001234604,0.001293536,0.00000955068],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9986197,0.0006381578,0.0001866193,0.00003602312,0.000004902321,0.00001022774,0.0001616551,0.00001279972,0.0003298191],"genre_scores_gemma":[0.9991969,0.0001347176,0.0002470415,0.00003003121,0.000007017041,0.000006880834,0.0001656588,0.000002953252,0.0002086907],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001248278,"threshold_uncertainty_score":0.004175901,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05956573017385619,"score_gpt":0.3845516860664789,"score_spread":0.3249859558926227,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}