{"id":"W4293094498","doi":"10.1200/jco.22.00364","title":"Circulating Tumor DNA Identifies Diverse Landscape of Acquired Resistance to Anti–Epidermal Growth Factor Receptor Therapy in Metastatic Colorectal Cancer","year":2022,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":67,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University of Ottawa; Ottawa Hospital; Queen's University; University of British Columbia","funders":"BC Cancer Foundation; Michael Smith Health Research BC; Terry Fox Research Institute; AstraZeneca","keywords":"Medicine; KRAS; Neuroblastoma RAS viral oncogene homolog; Colorectal cancer; Epidermal growth factor receptor; Internal medicine; Panitumumab; Oncology; Targeted therapy; Cancer research; Cetuximab; EGFR inhibitors; Cancer","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001367354,0.0001226989,0.0007626106,0.0001061608,0.00006248455,0.00001004684,0.0003068336,0.00008048748,0.0002153793],"category_scores_gemma":[0.002051253,0.0001118947,0.0002839431,0.0001729282,0.00008984343,0.000008778556,0.0001985163,0.0001967745,0.000001154267],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008196306,"about_ca_system_score_gemma":0.001036161,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007582105,"about_ca_topic_score_gemma":0.0004534216,"domain_scores_codex":[0.9974476,0.0004373653,0.001427858,0.0002280356,0.00024419,0.0002150215],"domain_scores_gemma":[0.9976318,0.0006058392,0.001233345,0.0001255343,0.0002618018,0.0001416083],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.009543894,0.001393183,0.3065377,0.0000538176,0.0006145232,0.0004025003,0.0007492591,0.00226023,0.6460919,0.0000792174,0.01781379,0.01445992],"study_design_scores_gemma":[0.01598741,0.01709059,0.7468599,0.0001091165,0.0001858524,0.0001332424,0.002517849,0.0001372353,0.1325888,0.0004610968,0.08320376,0.0007252114],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9959071,0.001299949,0.00003828948,0.0009668578,0.001359833,0.000180102,0.0001295047,0.000001734553,0.0001166137],"genre_scores_gemma":[0.9966385,0.001134819,0.0007242378,0.0009836029,0.0004249008,0.00001896202,0.000009892264,0.00001637127,0.00004866476],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5135032,"threshold_uncertainty_score":0.4562933,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05956573017385619,"score_gpt":0.3845516860664789,"score_spread":0.3249859558926227,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}