{"id":"W4293103132","doi":"10.1038/s42003-022-03819-6","title":"Egg-laying and locomotory screens with C. elegans yield a nematode-selective small molecule stimulator of neurotransmitter release","year":2022,"lang":"en","type":"article","venue":"Communications Biology","topic":"Genetics, Aging, and Longevity in Model Organisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary; Hospital for Sick Children; University of Toronto","funders":"CIHR Skin Research Training Centre; Canadian Institutes of Health Research; Agricultural Research Service; U.S. Department of Agriculture; Canada Research Chairs; Government of Canada; Oklahoma Medical Research Foundation; University of Minnesota","keywords":"Neurotransmitter; Nematode; Biology; Neuroscience; Zoology; Ecology; Central nervous system","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001688304,0.0001546558,0.0001948882,0.00007541719,0.0003145273,0.000008953803,0.0006258306,0.00009012234,0.00002005659],"category_scores_gemma":[0.00004715168,0.000155312,0.00005355944,0.0001227751,0.0003814963,0.000002831063,0.0006080111,0.0002682108,0.000001234082],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001283065,"about_ca_system_score_gemma":0.0001068673,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001183142,"about_ca_topic_score_gemma":0.0001326708,"domain_scores_codex":[0.9988926,0.0002947972,0.0002284678,0.0003116984,0.00005977677,0.0002126258],"domain_scores_gemma":[0.9984607,0.000066027,0.0001246646,0.001175342,0.0001055547,0.0000677798],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002093543,0.000382441,0.08389354,0.00005038146,0.0001965556,0.000003172777,0.001120368,0.001067789,0.9104113,0.00131608,0.0003222555,0.001026738],"study_design_scores_gemma":[0.01051708,0.01821988,0.1078887,0.0001913316,0.001114619,0.001016661,0.00608723,0.02204757,0.7045699,0.00287592,0.1210402,0.004430861],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9816895,0.002545614,0.01399122,0.0006911049,0.00003054899,0.0003731246,0.00005248803,0.00001980685,0.000606556],"genre_scores_gemma":[0.9943071,0.0004036158,0.004145657,0.000777124,0.00002049265,0.00009848749,0.0001388188,0.00002985398,0.0000788254],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2058414,"threshold_uncertainty_score":0.6333441,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02483672968417918,"score_gpt":0.2496149186078598,"score_spread":0.2247781889236806,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}