{"id":"W4293105474","doi":"10.1126/sciadv.abq0008","title":"AFF3, a susceptibility factor for autoimmune diseases, is a molecular facilitator of immunoglobulin class switch recombination","year":2022,"lang":"en","type":"article","venue":"Science Advances","topic":"T-cell and B-cell Immunology","field":"Immunology and Microbiology","cited_by":38,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Université de Montréal; Montreal Clinical Research Institute","funders":"","keywords":"Immunoglobulin class switching; Immunology; Antibody; Isotype; Rheumatoid arthritis; Biology; Immunoglobulin G; Human leukocyte antigen; B cell; Antigen; Monoclonal antibody","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0005584257,0.0002015837,0.0003716366,0.000200804,0.0008287556,0.0000168036,0.0009067744,0.00008004312,0.00126598],"category_scores_gemma":[0.0002694895,0.0001871029,0.0001832359,0.0006741143,0.001387567,0.0003839108,0.0003507558,0.0002459553,0.00005035552],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00018818,"about_ca_system_score_gemma":0.0003732162,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006505799,"about_ca_topic_score_gemma":0.000007252865,"domain_scores_codex":[0.9979771,0.0001789483,0.0004636118,0.0006670895,0.0001523196,0.0005608845],"domain_scores_gemma":[0.9986972,0.0001860323,0.0002889731,0.0005660424,0.0002327034,0.00002903468],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002465886,0.0003424736,0.001241501,0.00003595344,0.00003510861,0.000001009044,0.0006669948,0.00003611001,0.9755277,0.0006468862,0.0001182477,0.02110141],"study_design_scores_gemma":[0.001829596,0.001206653,0.004966897,0.00001232875,0.00003358242,0.00001271351,0.002110489,0.00002831655,0.9008253,0.004115633,0.08453935,0.0003192101],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9794288,0.01637617,0.0004526555,0.0005614161,0.00157101,0.0006478287,0.0007461015,0.0000767054,0.0001393308],"genre_scores_gemma":[0.9977804,0.00005158611,0.0002766648,0.0001232626,0.000004897858,0.0001686043,0.00007783821,0.00001053281,0.001506258],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0844211,"threshold_uncertainty_score":0.999647,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01057518359054693,"score_gpt":0.2615921559073486,"score_spread":0.2510169723168017,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}