{"id":"W4293105474","doi":"10.1126/sciadv.abq0008","title":"AFF3, a susceptibility factor for autoimmune diseases, is a molecular facilitator of immunoglobulin class switch recombination","year":2022,"lang":"en","type":"article","venue":"Science Advances","topic":"T-cell and B-cell Immunology","field":"Immunology and Microbiology","cited_by":38,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Université de Montréal; Montreal Clinical Research Institute","funders":"","keywords":"Immunoglobulin class switching; Immunology; Antibody; Isotype; Rheumatoid arthritis; Biology; Immunoglobulin G; Human leukocyte antigen; B cell; Antigen; Monoclonal antibody","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001339958,0.0005307146,0.0002440796,0.0003744089,0.000353141,0.0002316283,0.0001885733,0.000452343,0.002494133],"category_scores_gemma":[0.0001931248,0.00008578998,0.0003626853,0.0002513962,0.0002444667,0.0001314057,0.0002611597,0.0003934678,0.0004472376],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002436885,"about_ca_system_score_gemma":0.0001717098,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007959229,"about_ca_topic_score_gemma":0.0005725949,"domain_scores_codex":[0.9998933,0.00001954747,0.00000872626,0.000027093,0.00002997417,0.00002142084],"domain_scores_gemma":[0.9998292,0.00002907782,0.0000777126,0.00001021203,0.00001227846,0.00004147388],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004100491,0.00003391466,0.007658922,0.00006403826,0.00002673038,0.0008550111,0.00002873319,0.0001094177,0.9811306,0.0004966959,0.0003166385,0.008869233],"study_design_scores_gemma":[0.000193375,0.001134739,0.2161983,0.00007097742,0.0001994851,0.02653529,0.0002047583,0.004404223,0.7164629,0.001817683,0.0327061,0.00007211386],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9879708,0.002953203,0.00576784,0.0002606603,0.00006476156,0.0000235569,0.000885979,0.0002467112,0.001826437],"genre_scores_gemma":[0.9958434,0.0005233304,0.001904573,0.00008759676,0.00002315739,0.000009892008,0.0005640321,0.00001528725,0.001028827],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002494133,"threshold_uncertainty_score":0.008343697,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01057518359054693,"score_gpt":0.2615921559073486,"score_spread":0.2510169723168017,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}