{"id":"W4293148596","doi":"10.1055/s-0042-1747718","title":"Efficacy of Tezepelumab in Patients with Moderate-to-Severe Uncontrolled Asthma: A Pooled Analysis of the Phase 2b PATHWAY and Phase 3 NAVIGATOR Studies","year":2022,"lang":"en","type":"article","venue":"Pneumologie","topic":"Asthma and respiratory diseases","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Amgen (Canada)","funders":"","keywords":"Thymic stromal lymphopoietin; Medicine; Asthma; Post hoc; Monoclonal antibody; Post-hoc analysis; Pooled analysis; Phase (matter); Internal medicine; Immunology; Antibody; Meta-analysis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002022165,0.000177884,0.0008578529,0.0002645075,0.0001143084,0.00000422496,0.0001367732,0.00003351002,0.00004294754],"category_scores_gemma":[0.0004321836,0.0001019997,0.0001679339,0.001050646,0.0001575083,0.0000330733,0.0001977888,0.0001640193,4.447384e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008254845,"about_ca_system_score_gemma":0.0002004065,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001717847,"about_ca_topic_score_gemma":0.00001403597,"domain_scores_codex":[0.9984437,0.0002191949,0.0004158018,0.0003072575,0.0004043389,0.0002096752],"domain_scores_gemma":[0.9989376,0.0002067956,0.0002237044,0.0003607713,0.0001676131,0.000103493],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.06397373,0.01768293,0.8393875,0.0002654091,0.006849578,0.0002685426,0.003088339,0.01362424,0.008311705,0.00003895511,0.0001330226,0.04637604],"study_design_scores_gemma":[0.1199921,0.01163688,0.8557174,0.000178322,0.00410685,0.000006481202,0.003423448,0.001844146,0.002367097,0.00004227225,0.0002812065,0.0004038087],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.997759,0.0007949175,0.000007726019,0.0002077763,0.00004375401,0.0008931304,0.0002507455,0.00001691013,0.00002605802],"genre_scores_gemma":[0.9995109,0.000006162477,0.00002477237,0.0002696523,0.000009190582,0.00009763426,0.00002844546,0.00001326965,0.00003994051],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05601842,"threshold_uncertainty_score":0.4159426,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01817167772200928,"score_gpt":0.3052584889762631,"score_spread":0.2870868112542538,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}