{"id":"W4293152358","doi":"10.1101/2022.08.08.22278494","title":"Impact of age and SARS-CoV-2 breakthrough infection on humoral immune responses after three doses of COVID-19 mRNA vaccine","year":2022,"lang":"en","type":"preprint","venue":"medRxiv","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Centre for Disease Control; University of British Columbia; St. Paul's Hospital; AIDS Vancouver; Simon Fraser University","funders":"Canadian Institutes of Health Research; Simon Fraser University; Providence Health Care; Public Health Agency; Public Health Agency of Canada","keywords":"Neutralization; Immune system; Coronavirus disease 2019 (COVID-19); Vaccination; Medicine; Young adult; Antibody; Immunology; Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); Virology; Internal medicine; Disease","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004340585,0.0002433187,0.0002961126,0.0001639767,0.0001358185,0.0002016151,0.0001049809,0.0002256632,0.00120535],"category_scores_gemma":[0.0006792031,0.00007944874,0.0002197203,0.00007844559,0.000105179,0.0002394744,0.0001725513,0.0002638056,0.0001764964],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002382732,"about_ca_system_score_gemma":0.0001294748,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001231829,"about_ca_topic_score_gemma":0.001217058,"domain_scores_codex":[0.9998059,0.00002995935,0.00001458812,0.00004198039,0.00004341502,0.00006433897],"domain_scores_gemma":[0.9996282,0.00007249866,0.0001340906,0.00002552105,0.00005715324,0.0000825112],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0124383,0.0009222933,0.7437015,0.0001676432,0.0001332428,0.0004411282,0.0005470351,0.0003376716,0.2054375,0.0000453558,0.0002308292,0.03559758],"study_design_scores_gemma":[0.00003071657,0.01060028,0.9731945,0.000009323231,0.00006027351,0.0002863421,0.0001337189,0.0001477768,0.01498223,0.00001359405,0.0005357548,0.00000537584],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9995202,0.0001692634,0.0000397885,0.000004545279,0.000003595694,0.000007442717,0.00006638684,0.000002215688,0.0001866233],"genre_scores_gemma":[0.9994969,0.00004203893,0.00004152313,0.00001251135,0.000004493403,0.000009896537,0.0001307043,8.391511e-7,0.000261093],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001231829,"threshold_uncertainty_score":0.004032314,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07750939085066756,"score_gpt":0.4099531164653042,"score_spread":0.3324437256146367,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}