{"id":"W4293169084","doi":"10.3390/ijms23179534","title":"The Critical Role of AMPKα1 in Regulating Autophagy and Mitochondrial Respiration in IL-15-Stimulated mTORC1Weak Signal-Induced T Cell Memory: An Interplay between Yin (AMPKα1) and Yang (mTORC1) Energy Sensors in T Cell Differentiation","year":2022,"lang":"en","type":"article","venue":"International Journal of Molecular Sciences","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"Saskatchewan Cancer Agency; University of Saskatchewan","funders":"Canadian Institutes of Health Research","keywords":"Autophagy; mTORC1; AMPK; Cell biology; Respiration; Signal pathway; Mitochondrion; Energy metabolism; Chemistry; Signal transduction; Biology; Phosphorylation; Biochemistry; PI3K/AKT/mTOR pathway; Apoptosis; Protein kinase A; Botany; Endocrinology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001130032,0.0002246581,0.0001520832,0.0001630029,0.000167898,0.0002683933,0.0001259048,0.0002154468,0.0007609726],"category_scores_gemma":[0.0000639663,0.0001198421,0.0002048564,0.0000901137,0.0002254557,0.000234466,0.0001893125,0.0002961281,0.0001930531],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002001048,"about_ca_system_score_gemma":0.0001668972,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00012012,"about_ca_topic_score_gemma":0.0002332664,"domain_scores_codex":[0.9999141,0.00001090483,0.00001143098,0.0000232263,0.00001292823,0.00002747551],"domain_scores_gemma":[0.9999495,0.000003290385,0.00001854652,0.000005060047,0.000005674538,0.00001786778],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002548859,0.00001411903,0.0004530963,0.00003006076,0.000002888979,0.00003687554,0.00001209436,0.00004245146,0.9983981,0.0001020033,0.00001455851,0.0006388223],"study_design_scores_gemma":[0.0000501037,0.000301118,0.02181297,0.00001924821,0.00002634223,0.0003700905,0.00007083349,0.001117308,0.9742516,0.0002437205,0.001730611,0.000006121233],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.995949,0.001723734,0.001425275,0.00009901066,0.00002461784,0.00001393271,0.0001365974,0.00001568961,0.0006121984],"genre_scores_gemma":[0.9982577,0.0004155356,0.0005871949,0.0000403224,0.00000993226,0.00001800554,0.0001466906,0.000003867661,0.0005208782],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007609726,"threshold_uncertainty_score":0.002545714,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01002584016173548,"score_gpt":0.2685289143383016,"score_spread":0.2585030741765661,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}