{"id":"W4293171087","doi":"10.1002/ccr3.6269","title":"Protein S gene mutation c.<scp>946C</scp> &gt; T (p.<scp>R316C</scp>) contributed to ischemic stroke in a man with von Willebrand disease type 3 caused by two novel <scp>VWF</scp> gene mutations, c.<scp>2328delT</scp> (p.<scp>A778Lfs</scp>* 23) and c.<scp>6521G</scp> &gt; T (p.<scp>C2174F</scp>)","year":2022,"lang":"en","type":"article","venue":"Clinical Case Reports","topic":"Platelet Disorders and Treatments","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Foothills Medical Centre; University of Calgary","funders":"National Natural Science Foundation of China","keywords":"Medicine; Mutation; Ischemic stroke; Gene; Von Willebrand factor; Stroke (engine); Disease; Von Willebrand disease; Molecular biology; Genetics; Immunology; Internal medicine; Ischemia; Biology; Platelet","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaresearch","metaepi_narrow","sts","scholarly_communication","research_integrity"],"consensus_categories":["metaepi_narrow","research_integrity"],"category_scores_codex":[0.006042939,0.004449169,0.006649469,0.002464908,0.002510125,0.001053445,0.001330534,0.002258731,0.00004713112],"category_scores_gemma":[0.04959618,0.004438103,0.001880823,0.0053166,0.001732071,0.001466034,0.001717263,0.00500175,0.0003811628],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001710924,"about_ca_system_score_gemma":0.00417016,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001150778,"about_ca_topic_score_gemma":0.0008612619,"domain_scores_codex":[0.9707206,0.002001519,0.008573377,0.007519822,0.005194949,0.00598976],"domain_scores_gemma":[0.9660487,0.01426388,0.005787974,0.004752002,0.002567414,0.006580079],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"case_report","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0004573568,0.02489167,0.2072094,0.002372967,0.008629225,0.4175845,0.009827145,0.004169007,0.106952,0.0002425234,0.2145178,0.003146396],"study_design_scores_gemma":[0.1062215,0.01827302,0.1059707,0.003118381,0.01615147,0.09441315,0.0238864,0.01012398,0.0993719,0.00191379,0.518934,0.001621692],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9603271,0.01242065,0.001148946,0.0004262294,0.00195508,0.0138264,0.005602579,0.001192309,0.003100628],"genre_scores_gemma":[0.9517421,0.001222975,0.002771181,0.003132284,0.001312274,0.003729593,0.01316576,0.00128163,0.02164224],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3231713,"threshold_uncertainty_score":0.9999835,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01952708707707531,"score_gpt":0.2958790940487381,"score_spread":0.2763520069716628,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}