{"id":"W4293181930","doi":"10.1038/s41467-022-32763-6","title":"BRAT1 links Integrator and defective RNA processing with neurodegeneration","year":2022,"lang":"en","type":"article","venue":"Nature Communications","topic":"RNA and protein synthesis mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":29,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; Hospital for Sick Children; University of Toronto","funders":"Medical Research Council; Přírodovědecká Fakulta, Univerzita Karlova; Grantová Agentura, Univerzita Karlova; Univerzita Karlova v Praze; Grantová Agentura České Republiky; Ministerstvo Školství, Mládeže a Tělovýchovy","keywords":"Neurodegeneration; Biology; Integrator; Phenotype; Histone; Small nucleolar RNA; Non-coding RNA; Neuroscience; Gene expression; Gene; Cell biology; Computational biology; Disease; Genetics; Medicine; Computer science; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002065213,0.0007359921,0.0003182838,0.000576384,0.0002368066,0.0004792799,0.0004510395,0.0006176382,0.001593248],"category_scores_gemma":[0.0003628314,0.0002564696,0.0002234579,0.0002087292,0.0004471841,0.000233989,0.0006186468,0.0007049718,0.0005289025],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003296589,"about_ca_system_score_gemma":0.0002239034,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003731683,"about_ca_topic_score_gemma":0.0004902401,"domain_scores_codex":[0.9997441,0.00003097939,0.00001933156,0.00008002155,0.00008083443,0.00004473644],"domain_scores_gemma":[0.9996144,0.00004072285,0.0002088296,0.00002625256,0.00002070128,0.00008908525],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001812634,0.00002567627,0.00233456,0.00005087408,0.00001982979,0.0009578755,0.00001967667,0.0001974002,0.9941332,0.0002260256,0.0001596052,0.001694055],"study_design_scores_gemma":[0.00004046544,0.0002875584,0.05048768,0.00003076462,0.00005495406,0.009989066,0.00006536738,0.003498581,0.9314854,0.0005328884,0.003509093,0.00001828926],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9914137,0.002737298,0.003859994,0.000198536,0.00005055076,0.0000127341,0.0003565178,0.0001993288,0.00117136],"genre_scores_gemma":[0.9968545,0.0005868949,0.001064972,0.00005916359,0.00001126889,0.00000945779,0.000370834,0.00002291908,0.0010201],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001593248,"threshold_uncertainty_score":0.005329967,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01011252371316015,"score_gpt":0.2547314810207693,"score_spread":0.2446189573076091,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}