{"id":"W4293187663","doi":"10.26434/chemrxiv-2022-bj274","title":"Identification and Utilization of a Chemical Probe to Interrogate the Roles of PIKfyve in the Lifecycle of β-Coronaviruses","year":2022,"lang":"en","type":"preprint","venue":"ChemRxiv","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; Genentech; National Institutes of Health; Ministero dello Sviluppo Economico; Genome Canada; Fundação de Amparo à Pesquisa do Estado de São Paulo; Ontario Ministry of Economic Development and Innovation; European Federation of Pharmaceutical Industries and Associations; Merck KGaA; Novartis Pharma; North Carolina Biotechnology Center; Pfizer","keywords":"Kinome; Cell biology; Biology; Chemical biology; Biochemistry; Chemistry; Antimycobacterial; Kinase","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007383988,0.000107708,0.0002871931,0.0001294948,0.00001572884,0.00001012434,0.000362549,0.00009022484,0.00001281724],"category_scores_gemma":[0.000456032,0.00006999885,0.00007977232,0.0002919454,0.0001753089,0.00002155147,0.0004755576,0.0003267752,0.000001042404],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004444413,"about_ca_system_score_gemma":0.0001462035,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001245982,"about_ca_topic_score_gemma":0.00003438375,"domain_scores_codex":[0.9987462,0.00008779797,0.0004233834,0.0002436559,0.0003925265,0.00010641],"domain_scores_gemma":[0.9989578,0.0001511585,0.0002132533,0.0005299969,0.0001352075,0.00001254813],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003359216,0.0002987284,0.03686157,0.001181788,0.0000524275,0.000001855061,0.01122864,0.00000328785,0.9466992,0.0002115272,0.00007427176,0.003050756],"study_design_scores_gemma":[0.000348115,0.00006501382,0.0180716,0.0002799596,0.00005576043,0.000003125985,0.001970238,0.0002956518,0.9772529,0.0007864942,0.0008126628,0.00005845494],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9975601,0.0006848752,0.00008594324,0.0005468422,0.00003434464,0.0008526894,0.000007168232,0.000007568933,0.0002203983],"genre_scores_gemma":[0.9987624,0.00002357038,0.00003049028,0.0009232314,0.0000283174,0.0002003678,0.00001089472,0.00001284965,0.000007925657],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0305537,"threshold_uncertainty_score":0.285447,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0927766791902682,"score_gpt":0.391747825687482,"score_spread":0.2989711464972137,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}