{"id":"W4293193969","doi":"10.2139/ssrn.4032800","title":"Activation of <i>Nrf2</i> By Genetic Alteration of <i>Keap1</i> Confers Resistance to Chemotherapy in Head and Neck Squamous Carcinoma","year":2022,"lang":"en","type":"article","venue":"SSRN Electronic Journal","topic":"Genomics, phytochemicals, and oxidative stress","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto","funders":"","keywords":"Head and neck; KEAP1; Chemistry; Medicine; Gene; Transcription factor; Biochemistry; Surgery","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001190142,0.0002511638,0.000251973,0.0002133439,0.0001388065,0.0002003912,0.0002679177,0.0002443458,0.003390109],"category_scores_gemma":[0.0001231831,0.0001793117,0.0002116699,0.000228432,0.000298353,0.0001636013,0.000154187,0.0005514015,0.0007473759],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002905969,"about_ca_system_score_gemma":0.0002748068,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001194601,"about_ca_topic_score_gemma":0.001500931,"domain_scores_codex":[0.9998912,0.00001876072,0.00001600124,0.00002351896,0.00002705297,0.00002347746],"domain_scores_gemma":[0.999881,0.00001955691,0.00003574711,0.00002354965,0.00001093847,0.00002915714],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000764116,0.00001810373,0.00006867597,0.00001000419,0.000002634013,0.00003058256,0.000006410795,0.00003427061,0.9992392,0.00005764188,0.0000368792,0.000419298],"study_design_scores_gemma":[0.00001853731,0.0001763803,0.003027572,0.000003653075,0.00001577711,0.0002163581,0.00003559915,0.0006161547,0.9940935,0.00005110453,0.001740465,0.00000507915],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9949846,0.0002605797,0.001967862,0.0001734038,0.0000392374,0.00002846725,0.0008952751,0.0001379732,0.001512582],"genre_scores_gemma":[0.9939319,0.0001981709,0.001245007,0.00004778296,0.000007057646,0.00002484514,0.0009283048,0.00004037351,0.003576675],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003390109,"threshold_uncertainty_score":0.01134104,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007703962870705658,"score_gpt":0.2345302932420842,"score_spread":0.2268263303713786,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}