{"id":"W4293194990","doi":"10.1038/s41580-022-00518-2","title":"Regulation, functions and transmission of bivalent chromatin during mammalian development","year":2022,"lang":"en","type":"review","venue":"Nature Reviews Molecular Cell Biology","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":191,"is_retracted":false,"has_abstract":false,"ca_institutions":"Lunenfeld-Tanenbaum Research Institute; University of Toronto; Mount Sinai Hospital","funders":"Canadian Institutes of Health Research","keywords":"Bivalent chromatin; Chromatin; PRC2; Biology; H3K4me3; Histone; Cell biology; Polycomb-group proteins; Epigenetics; Chromatin remodeling; Histone-modifying enzymes; ChIA-PET; Histone H3; Regulation of gene expression; Bivalent (engine); Genetics; Gene; Gene expression; Promoter; Repressor; Chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0005363061,0.000451146,0.001135506,0.0001888047,0.000146448,0.000009627764,0.0002541716,0.0009647047,0.0001471745],"category_scores_gemma":[0.00007277555,0.0003741223,0.0004356599,0.0002591058,0.00006754922,0.000002143528,0.0001989299,0.0004912417,0.000006516441],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004679121,"about_ca_system_score_gemma":0.0001959712,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000001621133,"about_ca_topic_score_gemma":0.00000149942,"domain_scores_codex":[0.9972113,0.0006776862,0.0009928673,0.0007195571,0.0001397471,0.0002588651],"domain_scores_gemma":[0.9985894,0.0000261634,0.0007003119,0.0005290244,0.00005117898,0.0001039385],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000006665635,0.00004445083,0.0000073255,0.009080984,0.00006707697,0.000002042828,0.00001258797,0.000003142434,0.0740613,0.00001780273,0.00004223612,0.9166544],"study_design_scores_gemma":[0.0001772685,0.0001249293,0.00001397345,0.0007415721,0.0002522503,0.000009025607,0.000002850281,9.373928e-7,0.02189542,0.00001416187,0.9764169,0.0003507044],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.000777974,0.9955043,0.001532566,0.000008444865,0.000178185,0.001037544,0.00003043063,0.000008625657,0.0009219344],"genre_scores_gemma":[0.0005094309,0.9935565,0.002886022,0.0000173564,0.00007833018,0.0001808291,0.002162546,0.00005706304,0.0005519067],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9763747,"threshold_uncertainty_score":0.9998711,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01847597208317702,"score_gpt":0.2949704826568021,"score_spread":0.2764945105736251,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}