{"id":"W4293197425","doi":"10.1007/978-1-0716-1006-0_715","title":"Neuropharmacological Modeling, Pharmacogenomics and Ion Channel Modulation","year":2022,"lang":"en","type":"book-chapter","venue":"Encyclopedia of Computational Neuroscience","topic":"Neuroscience and Neuropharmacology Research","field":"Neuroscience","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia","funders":"","keywords":"Pharmacogenomics; Modulation (music); Ion channel; Pharmacology; Medicine; Physics; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001508649,0.0007916265,0.0005955317,0.0003810593,0.0001884918,0.001194014,0.0009019305,0.0008807409,0.008555665],"category_scores_gemma":[0.0002885605,0.0002579956,0.0004127299,0.0006578226,0.0005623777,0.001383716,0.000461875,0.00111366,0.005299871],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004504349,"about_ca_system_score_gemma":0.0004190149,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008051367,"about_ca_topic_score_gemma":0.001157421,"domain_scores_codex":[0.9999346,0.000007335499,0.000003156448,0.00001694355,0.00003324564,0.000004848432],"domain_scores_gemma":[0.9999464,0.00002795999,0.000004078525,0.000007623061,0.00001045325,0.00000354014],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"theoretical_or_conceptual","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.0000759527,0.0001252241,0.0002477589,0.001546219,0.0000601743,0.0003521536,0.00008396909,0.03689998,0.04248111,0.4200836,0.1186493,0.3793944],"study_design_scores_gemma":[0.00001357938,0.00007853095,0.0004575324,0.0002225445,0.0000525246,0.001047522,0.00004869402,0.06994225,0.01231745,0.350722,0.5650535,0.00004393679],"study_design_candidate":"simulation_or_modeling","study_design_consensus":null,"genre_codex":"methods","genre_gemma":"methods","genre_scores_codex":[0.009300646,0.1863817,0.4477111,0.005633975,0.003944867,0.00009443838,0.001758675,0.002257943,0.3429165],"genre_scores_gemma":[0.1176065,0.2717733,0.1906477,0.003105715,0.002254186,0.0002709963,0.001894247,0.0008815678,0.4115657],"genre_candidate":"methods","genre_consensus":"methods","teacher_disagreement_score":0.008555665,"threshold_uncertainty_score":0.02862149,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07115436291022775,"score_gpt":0.3253599496378928,"score_spread":0.2542055867276651,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}