{"id":"W4293213938","doi":"10.1177/10781552221122057","title":"Elevated transaminases and development of cardiomyopathy in a 32-year-old woman with metastatic breast cancer after treatment with ribociclib followed by palbociclib","year":2022,"lang":"en","type":"article","venue":"Journal of Oncology Pharmacy Practice","topic":"Advanced Breast Cancer Therapies","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta; Alberta Health Services","funders":"","keywords":"Palbociclib; Medicine; Discontinuation; Metastatic breast cancer; Breast cancer; Internal medicine; Cardiomyopathy; Heart failure; Adverse effect; Cancer; Oncology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006431807,0.0002557157,0.0008313085,0.000229695,0.00008778083,0.000009196749,0.00008803471,0.00002473597,0.0002960311],"category_scores_gemma":[0.00002120965,0.0001783011,0.0000670135,0.0003794004,0.0001385029,0.0004579951,0.00002727703,0.0004822327,5.301381e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001200712,"about_ca_system_score_gemma":0.001649777,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001342733,"about_ca_topic_score_gemma":0.00009407804,"domain_scores_codex":[0.9978707,0.0004221258,0.0006448057,0.0002431087,0.000517052,0.0003022144],"domain_scores_gemma":[0.9981253,0.0003883163,0.0008942835,0.0001281356,0.0002813331,0.0001826473],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"not_applicable","study_design_scores_codex":[0.3338313,0.008542422,0.2840241,0.0003316584,0.008935471,0.01172185,0.02412646,0.0006839895,0.05024991,0.000004222341,0.0003119264,0.2772367],"study_design_scores_gemma":[0.1466327,0.01842495,0.05829601,0.0004493944,0.006068537,0.04594554,0.02436334,0.00006417435,0.02104246,0.000007812963,0.6779857,0.0007194561],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.988615,0.005447423,0.0002917852,0.00487225,0.00008240023,0.0005288474,0.00008255432,0.00001051516,0.00006917127],"genre_scores_gemma":[0.9842528,0.000894043,0.01336551,0.001057145,0.00004679445,0.0002182685,0.000007014825,0.00004458036,0.0001139156],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6776738,"threshold_uncertainty_score":0.7270906,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02452949682178768,"score_gpt":0.3570514982484372,"score_spread":0.3325220014266495,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}