{"id":"W4293229876","doi":"10.1136/ejhpharm-2022-eahp.275","title":"5PSQ-041 Safety and efficacy of high doses of irinotecan in patients with metastatic colorectal cancer treated with FOLFIRI scheme based on UGT1A1 genotype: a systematic review","year":2022,"lang":"en","type":"review","venue":"Section 5: Patient safety and quality assurance","topic":"Cancer therapeutics and mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Fundación Vital Fundazioa","keywords":"Irinotecan; Jadad scale; Medicine; FOLFIRI; Internal medicine; Colorectal cancer; Observational study; Oncology; Randomized controlled trial; Meta-analysis; Pharmacology; Cancer; Cochrane Library","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002935121,0.001049967,0.006569341,0.005532811,0.0003780669,0.001566467,0.001179864,0.001348417,0.005620036],"category_scores_gemma":[0.01532856,0.0006144986,0.008288337,0.006004361,0.0005196056,0.001238236,0.000943412,0.0007559828,0.0002909903],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002220069,"about_ca_system_score_gemma":0.00572881,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.007579393,"about_ca_topic_score_gemma":0.01988528,"domain_scores_codex":[0.9975421,0.0006825197,0.001001574,0.000271543,0.0003982938,0.0001039583],"domain_scores_gemma":[0.9891422,0.007088167,0.002450261,0.0001474221,0.001029472,0.0001424135],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"systematic_review","study_design_gemma":"systematic_review","study_design_scores_codex":[0.0004221413,0.00001447181,0.00165267,0.9561186,0.01841165,0.00007071388,0.0001029721,0.0001087592,0.0002363777,0.0001307871,0.001397087,0.02133375],"study_design_scores_gemma":[0.0007443122,0.0004700595,0.01446172,0.7253926,0.238738,0.0005606425,0.000250654,0.0001567363,0.0002537089,0.0003884459,0.01852764,0.00005548765],"study_design_candidate":"systematic_review","study_design_consensus":"systematic_review","genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.003368237,0.9936376,0.0001290268,0.0002986741,0.0001106543,0.0002998137,0.001696832,0.00001343168,0.0004457631],"genre_scores_gemma":[0.04255443,0.9538367,0.0004816405,0.001047625,0.0001170443,0.0006186484,0.001089415,0.000008898821,0.0002455452],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.007579393,"threshold_uncertainty_score":0.01880085,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02306352273737329,"score_gpt":0.2923180049184177,"score_spread":0.2692544821810444,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}