{"id":"W4293240264","doi":"10.1101/2022.08.24.22279143","title":"Variability in mRNA SARS-CoV-2 BNT162b2 vaccine immunogenicity is associated with differences in the gut microbiome and habitual dietary fibre intake","year":2022,"lang":"en","type":"preprint","venue":"medRxiv","topic":"Gut microbiota and health","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Children's Hospital; University of British Columbia","funders":"University of British Columbia","keywords":"Avidity; Immunogenicity; Microbiome; Antibody; Biology; Medicine; Immune system; Immunology; Microbiology; Food science; Bioinformatics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004755854,0.0001856212,0.0002429927,0.0002430272,0.0001901347,0.0003789795,0.0001534807,0.000288484,0.001976066],"category_scores_gemma":[0.001042052,0.0001622275,0.0002625463,0.0002866425,0.0001899036,0.0002342452,0.000312832,0.0002704443,0.0002528693],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000115941,"about_ca_system_score_gemma":0.00009281167,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001391917,"about_ca_topic_score_gemma":0.001584283,"domain_scores_codex":[0.9996808,0.00009251654,0.00003328633,0.0000985666,0.0000477311,0.00004710489],"domain_scores_gemma":[0.9993051,0.0001285336,0.0003441864,0.00007400216,0.00005034837,0.00009782342],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0005608664,0.00004679526,0.9931022,0.00001522235,0.00009511402,0.00003213165,0.00005317421,0.00004517526,0.004471381,0.00001521488,0.00005344386,0.001509399],"study_design_scores_gemma":[0.000003634731,0.00013949,0.9993149,0.000002329336,0.00001022414,0.0000713647,0.00005251705,0.0001031296,0.0002075375,0.00001475775,0.00007856842,0.000001512546],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9993737,0.00008770993,0.0001160492,0.00001163233,0.00000276986,0.000003585894,0.000225511,0.000002069747,0.0001770532],"genre_scores_gemma":[0.9995462,0.00002574303,0.00007581148,0.00001212161,0.000003066543,0.000004758595,0.0001784921,0.000001440501,0.0001522973],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001976066,"threshold_uncertainty_score":0.006610632,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0251052976097879,"score_gpt":0.271157876303063,"score_spread":0.2460525786932751,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}