{"id":"W4293240383","doi":"10.1101/2022.08.24.22279173","title":"Sex-stratified RNA-seq analysis reveals traumatic brain injury-induced transcriptional changes in the female hippocampus conducive to dementia","year":2022,"lang":"en","type":"preprint","venue":"medRxiv","topic":"Traumatic Brain Injury and Neurovascular Disturbances","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Montreal Neurological Institute and Hospital; McGill University","funders":"Fondation Brain Canada; ALS Society of Canada; McGill University","keywords":"Traumatic brain injury; Dementia; Candidate gene; Hippocampus; Neocortex; Neuroscience; Hippocampal formation; Biomarker; Neurodegeneration; Oncology; Medicine; Psychology; Bioinformatics; Biology; Disease; Internal medicine; Gene; Psychiatry; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001124132,0.0001536207,0.0002473779,0.0003684811,0.000243193,0.0002911962,0.0001106087,0.0001241169,0.001331807],"category_scores_gemma":[0.0002377506,0.000089102,0.0002797559,0.0002144229,0.0001222423,0.00007766857,0.0002109639,0.0001733655,0.0002614778],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008940568,"about_ca_system_score_gemma":0.0001271159,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009143819,"about_ca_topic_score_gemma":0.002099233,"domain_scores_codex":[0.9998953,0.000008327785,0.000005672235,0.00004508441,0.00001870384,0.00002680296],"domain_scores_gemma":[0.9998803,0.0000213007,0.00004018382,0.0000102322,0.00002795266,0.00001996863],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0009323257,0.00004409223,0.1786242,0.0001435845,0.0001577059,0.0004135536,0.0003196758,0.000197376,0.8067654,0.0001301151,0.0007478482,0.01152421],"study_design_scores_gemma":[0.00001396087,0.0002003188,0.9459449,0.00001940158,0.000118781,0.0007384765,0.0004237923,0.001141744,0.04905266,0.000188055,0.002140597,0.00001727464],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9956747,0.0004675127,0.001111452,0.0000365541,0.00001400341,0.00000701391,0.002296291,0.00002449878,0.0003681002],"genre_scores_gemma":[0.9945387,0.0002971911,0.001080938,0.0001193537,0.00001545497,0.00002967947,0.002876618,0.00002861786,0.001013449],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001331807,"threshold_uncertainty_score":0.004455328,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08081649077236072,"score_gpt":0.3299096951764196,"score_spread":0.2490932044040589,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}