{"id":"W4293242926","doi":"10.1126/science.abg6621","title":"Lysosomal GPCR-like protein LYCHOS signals cholesterol sufficiency to mTORC1","year":2022,"lang":"en","type":"article","venue":"Science","topic":"Cellular transport and secretion","field":"Biochemistry, Genetics and Molecular Biology","cited_by":132,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval","funders":"National Institute of General Medical Sciences; National Institute of Mental Health; National Institute of Diabetes and Digestive and Kidney Diseases; National Heart, Lung, and Blood Institute; National Institutes of Health; University of Notre Dame; Amgen","keywords":"mTORC1; GTPase; Cell biology; Biology; Biochemistry; Permease; Transmembrane protein; G protein-coupled receptor; Guanosine; Signal transduction; Receptor; PI3K/AKT/mTOR pathway; Transporter","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005190521,0.0001005974,0.00007508832,0.00008483961,0.0004334705,0.00004042416,0.0005517424,0.00002937591,0.0001459873],"category_scores_gemma":[0.00002191532,0.0001020811,0.00005264176,0.0004829936,0.0001593007,0.000007797258,0.0001843726,0.00008529355,0.00002468888],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003118805,"about_ca_system_score_gemma":0.000185721,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001884349,"about_ca_topic_score_gemma":0.00001179257,"domain_scores_codex":[0.9985407,0.00003017065,0.0001431874,0.0005012141,0.0004545976,0.0003301426],"domain_scores_gemma":[0.9994221,0.000001684873,0.00003996609,0.0003362914,0.00005889912,0.0001411029],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000259774,0.00005352966,0.001109736,0.000003121871,0.000001565802,0.000003090082,0.0001629447,0.0002881805,0.9977935,0.00007959985,0.00003559665,0.000443137],"study_design_scores_gemma":[0.0004243161,0.001109257,0.01455336,0.000009084251,0.000006983038,0.00002228279,0.0002921355,0.0002390412,0.758727,0.00007941984,0.22415,0.0003871494],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9921981,0.00009536404,0.006215586,0.0002102243,0.0002183782,0.0003538968,0.00001337781,0.00001615623,0.000678897],"genre_scores_gemma":[0.9975802,0.000002179354,0.000183388,0.0004942172,0.00007302301,0.0000866031,0.00009094084,0.00000925626,0.001480218],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2390666,"threshold_uncertainty_score":0.4162748,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008890004229746349,"score_gpt":0.233276484419658,"score_spread":0.2243864801899116,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}