{"id":"W4293242926","doi":"10.1126/science.abg6621","title":"Lysosomal GPCR-like protein LYCHOS signals cholesterol sufficiency to mTORC1","year":2022,"lang":"en","type":"article","venue":"Science","topic":"Cellular transport and secretion","field":"Biochemistry, Genetics and Molecular Biology","cited_by":132,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval","funders":"National Institute of General Medical Sciences; National Institute of Mental Health; National Institute of Diabetes and Digestive and Kidney Diseases; National Heart, Lung, and Blood Institute; National Institutes of Health; University of Notre Dame; Amgen","keywords":"mTORC1; GTPase; Cell biology; Biology; Biochemistry; Permease; Transmembrane protein; G protein-coupled receptor; Guanosine; Signal transduction; Receptor; PI3K/AKT/mTOR pathway; Transporter","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001134343,0.0003044298,0.0003831393,0.0003235475,0.0003349888,0.0004781017,0.0001693403,0.0003782128,0.001534991],"category_scores_gemma":[0.0001991774,0.0001306239,0.000261419,0.000224585,0.0003003614,0.0002281805,0.0004168842,0.0003977593,0.0009832751],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008367366,"about_ca_system_score_gemma":0.0004565824,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001201643,"about_ca_topic_score_gemma":0.002352959,"domain_scores_codex":[0.9998524,0.00001897845,0.000009225466,0.00004180353,0.0000433389,0.00003425709],"domain_scores_gemma":[0.9999164,0.000009608395,0.0000236904,0.000008483828,0.00001559582,0.00002609134],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001494673,0.00000517098,0.0005402306,0.00003383012,0.000004903304,0.0002057535,0.00001085488,0.0001050947,0.9975901,0.0003008757,0.0002100319,0.0008438174],"study_design_scores_gemma":[0.00003883102,0.00009067875,0.01981875,0.00001384431,0.00002272872,0.001238304,0.0001054079,0.005976656,0.9623466,0.0002785731,0.01004898,0.00002071288],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9879138,0.002243746,0.003681691,0.0005808893,0.00005833734,0.0000256578,0.001832179,0.0005095049,0.003154234],"genre_scores_gemma":[0.9921569,0.0006783581,0.002283432,0.0001611598,0.00001518094,0.00001448621,0.001812041,0.00005237461,0.002826204],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001534991,"threshold_uncertainty_score":0.006070912,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008890004229746349,"score_gpt":0.233276484419658,"score_spread":0.2243864801899116,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}