{"id":"W4293244159","doi":"10.1158/2767-9764.crc-22-0083","title":"Redirecting T-cell Activity with Anti-BCMA/Anti-CD3 Bispecific Antibodies in Chronic Lymphocytic Leukemia and Other B-cell Lymphomas","year":2022,"lang":"en","type":"article","venue":"Cancer Research Communications","topic":"Monoclonal and Polyclonal Antibodies Research","field":"Medicine","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"ZonMw; Auris Health","keywords":"Chronic lymphocytic leukemia; B cell; Cancer research; Cell culture; T cell; CD19; Antigen; Antibody; Medicine; Leukemia; Immunology; Biology; Immune system","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001838477,0.0002670412,0.0002406906,0.0002434846,0.0001161069,0.0002774225,0.0001603951,0.0002212007,0.0006890686],"category_scores_gemma":[0.00008882942,0.00009802254,0.0001982114,0.0002006828,0.0001316412,0.0001452605,0.0001612735,0.0003910317,0.0002519791],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003540701,"about_ca_system_score_gemma":0.0001965071,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006830485,"about_ca_topic_score_gemma":0.001348075,"domain_scores_codex":[0.9999105,0.00001922908,0.000008441906,0.00001512106,0.00002200986,0.00002461661],"domain_scores_gemma":[0.9999679,0.000006948271,0.000006990982,0.000004585564,0.00000473708,0.000008757759],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000255436,0.00008296107,0.0004584865,0.0001033559,0.00001044367,0.00009027746,0.00002010727,0.0001421851,0.9904051,0.00007992887,0.0001131119,0.008238539],"study_design_scores_gemma":[0.0001639442,0.001810478,0.00938742,0.00001900561,0.00006148657,0.001373243,0.0000331942,0.001934963,0.9731713,0.00008916755,0.01194758,0.000008249083],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9825993,0.01152141,0.003375155,0.00007670449,0.00003334515,0.00007518661,0.0001267246,0.0001245768,0.00206772],"genre_scores_gemma":[0.9919465,0.003849076,0.002134279,0.00008087287,0.00001559992,0.00009535216,0.0002805058,0.00001414285,0.001583669],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006890686,"threshold_uncertainty_score":0.00256896,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1152114811457825,"score_gpt":0.4062737692107027,"score_spread":0.2910622880649202,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}