{"id":"W4293244159","doi":"10.1158/2767-9764.crc-22-0083","title":"Redirecting T-cell Activity with Anti-BCMA/Anti-CD3 Bispecific Antibodies in Chronic Lymphocytic Leukemia and Other B-cell Lymphomas","year":2022,"lang":"en","type":"article","venue":"Cancer Research Communications","topic":"Monoclonal and Polyclonal Antibodies Research","field":"Medicine","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"ZonMw; Auris Health","keywords":"Chronic lymphocytic leukemia; B cell; Cancer research; Cell culture; T cell; CD19; Antigen; Antibody; Medicine; Leukemia; Immunology; Biology; Immune system","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["sts"],"consensus_categories":[],"category_scores_codex":[0.001603808,0.000238421,0.0004657348,0.0006567336,0.001651014,0.00009081682,0.0009164134,0.00007549898,0.0004491276],"category_scores_gemma":[0.00007617364,0.0002093756,0.00007946646,0.001558354,0.001110621,0.0001445866,0.001732585,0.001547748,0.00003079227],"about_ca_system_candidate":true,"about_ca_system_consensus":true,"about_ca_system_score_codex":0.008630629,"about_ca_system_score_gemma":0.006804486,"about_ca_topic_candidate":true,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.02116028,"about_ca_topic_score_gemma":0.002677021,"domain_scores_codex":[0.9962311,0.0008864299,0.000320963,0.000553406,0.001118936,0.0008891331],"domain_scores_gemma":[0.9969125,0.0008958537,0.0001040674,0.001552962,0.0002706766,0.000263907],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.002850407,0.001658243,0.3590299,0.002468196,0.0004164906,0.0004418873,0.007877821,0.002669859,0.572883,0.001927972,0.01124417,0.03653203],"study_design_scores_gemma":[0.01586003,0.002295503,0.1820283,0.001325504,0.0001345316,0.0004903326,0.007638367,0.04760684,0.06955154,0.0003131085,0.6713585,0.001397455],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9478111,0.02304116,0.000003913024,0.00235752,0.00004513769,0.0008695648,0.0001043687,0.00006486588,0.02570236],"genre_scores_gemma":[0.9756541,0.01649668,0.0002883695,0.0001290871,0.0001053134,0.0005941998,0.00003296094,0.0000643136,0.00663493],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6601143,"threshold_uncertainty_score":0.9996487,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1152114811457825,"score_gpt":0.4062737692107027,"score_spread":0.2910622880649202,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}