{"id":"W4293246796","doi":"10.1101/2022.05.11.491537","title":"Enteric bacterial infection in <i>Drosophila</i> induces whole-body alterations in metabolic gene expression independently of the Immune Deficiency (Imd) signalling pathway","year":2022,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Invertebrate Immune Response Mechanisms","field":"Immunology and Microbiology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Alberta Children's Hospital; University of Calgary","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; National Institutes of Health","keywords":"Biology; Gene expression; Innate immune system; Gene; Transcription factor; Transcriptome; Cell biology; Signal transduction; Immune system; Metabolic pathway; Gene expression profiling; Regulation of gene expression; Lipid metabolism; Downregulation and upregulation; Microbiology; Immunology; Genetics; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00005636001,0.0003002036,0.0001362791,0.000190629,0.0001189107,0.0002632694,0.0001091312,0.000158993,0.0008844116],"category_scores_gemma":[0.00004542953,0.000126906,0.0001481286,0.00007406155,0.0001993271,0.0001123822,0.0001558361,0.0004235998,0.0002680473],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003671507,"about_ca_system_score_gemma":0.0001075649,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009604659,"about_ca_topic_score_gemma":0.001844249,"domain_scores_codex":[0.9999112,0.00001110165,0.000006890574,0.00003110231,0.00001840503,0.00002137117],"domain_scores_gemma":[0.9999198,0.000008323232,0.00003679579,0.000007956342,0.000007366264,0.00001975268],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003904798,0.000003451852,0.0003886888,0.00001515418,0.000002358898,0.00001848099,0.000004023656,0.00001237189,0.9991472,0.00001772717,0.0000261774,0.0003252489],"study_design_scores_gemma":[0.00001469663,0.0001994525,0.08274537,0.00001652887,0.00002194051,0.0003507791,0.0001057863,0.0008119697,0.9132349,0.00005095419,0.002439766,0.000007744837],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9954877,0.0008100704,0.001109567,0.0000890321,0.00001250024,0.00001169572,0.001107399,0.00008324569,0.001288723],"genre_scores_gemma":[0.9951853,0.0003722672,0.001072837,0.0001367504,0.000004968277,0.00002331177,0.001148459,0.00003642418,0.002019637],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009604659,"threshold_uncertainty_score":0.002958655,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01264907529355695,"score_gpt":0.2115484635799139,"score_spread":0.198899388286357,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}