{"id":"W4293253650","doi":"10.1101/2022.08.22.504793","title":"Chromosome 9p21.3 Coordinates Cell Intrinsic and Extrinsic Tumor Suppression","year":2022,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Single-cell and spatial transcriptomics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network; University of Toronto; Ontario Institute for Cancer Research","funders":"National Cancer Institute; National Institutes of Health; Marie-Josée and Henry R. Kravis Center for Molecular Oncology; Jane Coffin Childs Memorial Fund for Medical Research; Edward P. Evans Foundation; Memorial Sloan-Kettering Cancer Center; Cycle for Survival; Howard Hughes Medical Institute","keywords":"Biology; CDKN2A; Carcinogenesis; Cancer research; Genetics; Somatic cell; Cancer; Chromosome; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002115079,0.0003621191,0.0002398661,0.0003270083,0.0002100142,0.0004473811,0.0003725684,0.0004074523,0.001831752],"category_scores_gemma":[0.0001968749,0.0001893007,0.0002013483,0.0001494115,0.0004510631,0.0002390788,0.0005413123,0.0008255886,0.0007721609],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004344675,"about_ca_system_score_gemma":0.0002498554,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000603741,"about_ca_topic_score_gemma":0.0009039217,"domain_scores_codex":[0.9997798,0.00003563525,0.00001806337,0.00007875639,0.00005510229,0.00003272629],"domain_scores_gemma":[0.9998528,0.00003120198,0.00005742881,0.00002546988,0.00001012316,0.00002297973],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006815253,0.0000117175,0.0005259215,0.00002336948,0.000004741803,0.0001355542,0.00001543748,0.0005872442,0.9958243,0.001009385,0.00009291073,0.001701191],"study_design_scores_gemma":[0.0000273335,0.0001276383,0.007559523,0.00001079702,0.0000223905,0.000842749,0.00004346453,0.006536887,0.9752204,0.0006040828,0.008994189,0.00001054514],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9570035,0.001537663,0.0331015,0.0003967291,0.00009363458,0.00006295664,0.001427021,0.000559054,0.005817784],"genre_scores_gemma":[0.9900398,0.0005263467,0.006007085,0.00004929345,0.00001528702,0.00004241947,0.0006055596,0.00006216828,0.002651993],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001831752,"threshold_uncertainty_score":0.006127775,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009236241852952331,"score_gpt":0.201538442922365,"score_spread":0.1923022010694126,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}