{"id":"W4293255516","doi":"10.1111/gtc.12979","title":"<i>N</i>‐(3,4‐dimethoxyphenethyl)‐6‐methyl‐2,3,4,<scp>9‐tetrahydro‐1</scp><i>H</i>‐carbazol‐1‐amine inhibits bladder cancer progression by suppressing <scp>YAP1</scp>/<scp>TAZ</scp>","year":2022,"lang":"en","type":"article","venue":"Genes to Cells","topic":"Hippo pathway signaling and YAP/TAZ","field":"Biochemistry, Genetics and Molecular Biology","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto; University Health Network","funders":"Japan Society for the Promotion of Science; Fujifilm Corporation; Japan Agency for Medical Research and Development","keywords":"YAP1; Biology; Cancer research; Phosphorylation; Hippo signaling pathway; Cancer; Kinase; In vitro; Bladder cancer; Cell; Cell biology; Cancer cell; Pharmacology; Biochemistry; Genetics; Transcription factor; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00004786958,0.0002874435,0.0001615269,0.0001823553,0.0001219858,0.0001009594,0.0001959708,0.0001591192,0.001794057],"category_scores_gemma":[0.00006256302,0.00006819345,0.0001758099,0.0001055187,0.0001324749,0.0001075022,0.0001363229,0.0003584676,0.000455807],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001944255,"about_ca_system_score_gemma":0.0002491014,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001008497,"about_ca_topic_score_gemma":0.002232117,"domain_scores_codex":[0.9999635,0.000005841126,0.000001902937,0.000008157148,0.000009163861,0.00001133885],"domain_scores_gemma":[0.9999738,0.000004390088,0.000007689936,0.000002888923,0.000003469641,0.000007762143],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001628615,0.00004722746,0.0001313401,0.0001142401,0.000007767248,0.00007785163,0.000007882278,0.000202732,0.994028,0.0001223597,0.0002530515,0.004844754],"study_design_scores_gemma":[0.00008479747,0.0009019051,0.003528467,0.000008342593,0.00001449845,0.0004410289,0.00001232314,0.0009614624,0.9874955,0.00003934006,0.006503531,0.000008827803],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9671437,0.01018616,0.006891039,0.0003835537,0.0001358832,0.0001834892,0.001102124,0.0004605477,0.01351343],"genre_scores_gemma":[0.9890432,0.003621271,0.002747804,0.0001090586,0.00003145423,0.00007259979,0.0007602296,0.00002447227,0.003589822],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001794057,"threshold_uncertainty_score":0.00600177,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01031729711552221,"score_gpt":0.2586606893499123,"score_spread":0.2483433922343901,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}