{"id":"W4293255516","doi":"10.1111/gtc.12979","title":"<i>N</i>‐(3,4‐dimethoxyphenethyl)‐6‐methyl‐2,3,4,<scp>9‐tetrahydro‐1</scp><i>H</i>‐carbazol‐1‐amine inhibits bladder cancer progression by suppressing <scp>YAP1</scp>/<scp>TAZ</scp>","year":2022,"lang":"en","type":"article","venue":"Genes to Cells","topic":"Hippo pathway signaling and YAP/TAZ","field":"Biochemistry, Genetics and Molecular Biology","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto; University Health Network","funders":"Japan Society for the Promotion of Science; Fujifilm Corporation; Japan Agency for Medical Research and Development","keywords":"YAP1; Biology; Cancer research; Phosphorylation; Hippo signaling pathway; Cancer; Kinase; In vitro; Bladder cancer; Cell; Cell biology; Cancer cell; Pharmacology; Biochemistry; Genetics; Transcription factor; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001415097,0.001251589,0.001017302,0.0003637891,0.001143249,0.0003007507,0.001445649,0.0007654089,0.00009699324],"category_scores_gemma":[0.0005866445,0.001292151,0.0005694596,0.001086822,0.0002793388,0.00004216031,0.001548676,0.0009943899,0.0001646127],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001675843,"about_ca_system_score_gemma":0.0005578601,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002000998,"about_ca_topic_score_gemma":0.00005317333,"domain_scores_codex":[0.9918396,0.0009011019,0.001186614,0.002420665,0.001407576,0.002244377],"domain_scores_gemma":[0.9958384,0.0006226322,0.0006449349,0.001540053,0.0003553604,0.0009986175],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001853054,0.0004199614,0.0005695453,0.0001197665,0.0002639036,0.0000497669,0.001273052,0.003930085,0.9044991,0.000003621576,0.08062814,0.008224563],"study_design_scores_gemma":[0.000819276,0.0006132378,0.00004058313,0.00005827413,0.0001187233,0.00003050186,0.0006609839,0.0001764591,0.5720287,0.00002745099,0.4252434,0.0001824096],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9544671,0.03585143,0.001114036,0.0001243286,0.002014515,0.001295932,0.00108791,0.0002408824,0.003803831],"genre_scores_gemma":[0.9269963,0.002769106,0.009137606,0.004468923,0.002797014,0.001626661,0.002398488,0.0007423168,0.0490636],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3446153,"threshold_uncertainty_score":0.9989528,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01031729711552221,"score_gpt":0.2586606893499123,"score_spread":0.2483433922343901,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}