{"id":"W4293275795","doi":"10.1371/journal.pcbi.1010458","title":"Computer simulations of Template-Directed RNA Synthesis driven by temperature cycling in diverse sequence mixtures","year":2022,"lang":"en","type":"article","venue":"PLoS Computational Biology","topic":"RNA and protein synthesis mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Sequence (biology); Protocell; RNA; Nucleotide; Biology; Base pair; Computational biology; Random sequence; Genetics; DNA; Mathematics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004018664,0.0006019722,0.001082338,0.0005825801,0.000955345,0.0009496979,0.001032725,0.001870499,0.004023151],"category_scores_gemma":[0.002496583,0.0005283658,0.0007677269,0.0008616963,0.00115828,0.0008275814,0.0006654717,0.001130785,0.0002955105],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001284809,"about_ca_system_score_gemma":0.001388471,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0182487,"about_ca_topic_score_gemma":0.008836594,"domain_scores_codex":[0.9997759,0.00006579489,0.000009318042,0.00002830656,0.00003930198,0.00008135983],"domain_scores_gemma":[0.9986194,0.0008687473,0.00008409072,0.00005393171,0.0001714636,0.0002023598],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"simulation_or_modeling","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.0001139462,0.00006176343,0.00119881,0.0000288863,0.00002406501,0.0001036324,0.0000498092,0.994368,0.0006999805,0.002433944,0.0002779258,0.0006392277],"study_design_scores_gemma":[0.00005546915,0.00003884207,0.0004304913,0.000007685761,0.000007461596,0.000009182403,0.00003495768,0.997772,0.0003303349,0.0009809295,0.0003237511,0.000008803806],"study_design_candidate":"simulation_or_modeling","study_design_consensus":"simulation_or_modeling","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.969675,0.0002668566,0.01075184,0.0005252506,0.00009751016,0.00008189727,0.0007743898,0.0001872742,0.01763986],"genre_scores_gemma":[0.9924378,0.0001380167,0.004044184,0.0001207415,0.00001431963,0.0002051726,0.0006758845,0.00005484018,0.002308973],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0182487,"threshold_uncertainty_score":0.03628498,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01881483496305301,"score_gpt":0.2571182933635648,"score_spread":0.2383034584005118,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}