{"id":"W4293275795","doi":"10.1371/journal.pcbi.1010458","title":"Computer simulations of Template-Directed RNA Synthesis driven by temperature cycling in diverse sequence mixtures","year":2022,"lang":"en","type":"article","venue":"PLoS Computational Biology","topic":"RNA and protein synthesis mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Sequence (biology); Protocell; RNA; Nucleotide; Biology; Base pair; Computational biology; Random sequence; Genetics; DNA; Mathematics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001128601,0.0001314639,0.0001998784,0.00009711503,0.0001486857,0.000007492129,0.0002184703,0.0001183787,0.0001382379],"category_scores_gemma":[0.00008960477,0.0001345558,0.00006349976,0.0001519231,0.00006834645,0.000004117727,0.0001657135,0.0001194318,0.000002461929],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002394855,"about_ca_system_score_gemma":0.00006233304,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002609932,"about_ca_topic_score_gemma":0.000006877574,"domain_scores_codex":[0.9987862,0.0003288889,0.000267512,0.0003281749,0.0001224889,0.0001668004],"domain_scores_gemma":[0.9993839,0.0002388082,0.0001295548,0.0001343068,0.0000773148,0.00003610303],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005873435,0.0001058879,0.002202926,0.000008744586,0.00006167479,0.000002709201,0.00004226945,0.1306403,0.8658375,0.000158619,0.0003219917,0.0005586702],"study_design_scores_gemma":[0.000814632,0.0005126683,0.001492322,0.00003795694,0.0000386144,0.00002151677,0.00006682108,0.07608703,0.9161522,0.002886771,0.001390263,0.0004992443],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9962962,0.0001903915,0.002316678,0.0001702568,0.0001077007,0.0002108005,0.0006455876,0.00002173307,0.00004064522],"genre_scores_gemma":[0.9910623,0.00001140528,0.007648495,0.0002042368,0.00006089247,0.00005193826,0.0009258115,0.0000139395,0.00002098371],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05455323,"threshold_uncertainty_score":0.5487025,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01881483496305301,"score_gpt":0.2571182933635648,"score_spread":0.2383034584005118,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}