{"id":"W4293332018","doi":"10.1161/circulationaha.122.061481","title":"Aptamer Proteomics for Biomarker Discovery in Heart Failure With Reduced Ejection Fraction","year":2022,"lang":"en","type":"letter","venue":"Circulation","topic":"Advanced Proteomics Techniques and Applications","field":"Chemistry","cited_by":38,"is_retracted":false,"has_abstract":false,"ca_institutions":"Montreal Heart Institute","funders":"","keywords":"Medicine; Ejection fraction; Aptamer; Biomarker; Heart failure; Biomarker discovery; Proteomics; Cardiology; Heart failure with preserved ejection fraction; Internal medicine; Computational biology; Molecular biology; Genetics; Gene; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003021518,0.0008411462,0.0012231,0.0005946111,0.001594224,0.002491631,0.0009054577,0.01761788,0.003882292],"category_scores_gemma":[0.009167478,0.0004837665,0.0007659639,0.0003147652,0.002500047,0.001679389,0.0008871441,0.01547282,0.003475206],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002217599,"about_ca_system_score_gemma":0.001102627,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001025601,"about_ca_topic_score_gemma":0.002077007,"domain_scores_codex":[0.9984652,0.0004595085,0.0001095947,0.0001718287,0.000631718,0.0001622528],"domain_scores_gemma":[0.9957215,0.003178487,0.0001205867,0.0001165765,0.0005179137,0.0003449425],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000595492,0.0001527778,0.000767591,0.0002425403,0.00005690415,0.002999173,0.00009691916,0.0002479952,0.004683371,0.007817524,0.927183,0.05515658],"study_design_scores_gemma":[0.0008797404,0.0004815068,0.001977428,0.0002915795,0.0001013669,0.00437189,0.0002144934,0.005246984,0.008683562,0.04748261,0.9301629,0.0001060563],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"commentary","genre_gemma":"empirical","genre_scores_codex":[0.0022966,0.01348197,0.003072507,0.9066232,0.06581713,0.00008533309,0.0001816251,0.0002010635,0.008240557],"genre_scores_gemma":[0.0401344,0.01483531,0.004427923,0.7483871,0.1618069,0.0003542002,0.0001142964,0.00009481941,0.02984506],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.01761788,"threshold_uncertainty_score":0.01608992,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01794508341520734,"score_gpt":0.2711893060951933,"score_spread":0.2532442226799859,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}