{"id":"W4293332312","doi":"10.1161/circulationaha.122.061754","title":"Efficacy and Safety of Dapagliflozin According to Frailty in Patients With Heart Failure: A Prespecified Analysis of the DELIVER Trial","year":2022,"lang":"en","type":"article","venue":"Circulation","topic":"Diabetes Treatment and Management","field":"Medicine","cited_by":150,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Relypsa; National Medical Research Council; Respicardia; American Regent; National Heart, Lung, and Blood Institute; Japan Heart Foundation; Vifor Pharma; Daiichi-Sankyo; University of Glasgow; Pfizer; Moderna; Medical Research Council; Verily Life Sciences; British Heart Foundation; Cytokinetics; Ionis Pharmaceuticals; National Institutes of Health; Regeneron Pharmaceuticals; Sarepta Therapeutics; Japan Agency for Medical Research and Development; Sanofi Pasteur; Universitair Medisch Centrum Groningen; Kowa Company; Celladon Corporation; Defense Acquisition Program Administration; Boston Scientific Corporation; Esperion Therapeutics; Alnylam Pharmaceuticals; Novo Nordisk; MyoKardia; Daiichi Sankyo Europe; Servier; Bayer; Gilead Sciences; National Institute of Diabetes and Digestive and Kidney Diseases; Sanofi; GlaxoSmithKline; Amgen; AstraZeneca; Lundbeckfonden; Eli Lilly and Company; Bristol-Myers Squibb","keywords":"Medicine; Dapagliflozin; Heart failure; Ejection fraction; Hazard ratio; Clinical endpoint; Internal medicine; Tolerability; Randomized controlled trial; Canadian Cardiovascular Society; Cardiology; Confidence interval; Adverse effect; Myocardial infarction; Diabetes mellitus; Angina; Type 2 diabetes","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001200027,0.00004876281,0.0001925431,0.0001952171,0.00003420671,0.000003167273,0.00003241964,0.00001167038,0.00004288884],"category_scores_gemma":[0.00002858621,0.00003514716,0.00004570139,0.0007212655,0.00001219184,0.00003052638,0.00005775678,0.00003541657,2.179112e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006474157,"about_ca_system_score_gemma":0.00001055541,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002892788,"about_ca_topic_score_gemma":0.00001769528,"domain_scores_codex":[0.9993732,0.00004599124,0.0001700004,0.000118884,0.0002300417,0.00006188561],"domain_scores_gemma":[0.9996728,0.00003610381,0.00007325108,0.0001677844,0.00003065306,0.00001940451],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.006843124,0.0002560478,0.9838997,0.000009890789,0.0003255286,1.13029e-7,0.0002826138,0.005669321,0.0002153845,0.00006184913,0.0000356108,0.002400803],"study_design_scores_gemma":[0.01988222,0.0002285983,0.978272,0.00001660096,0.0006823172,1.761074e-8,0.00009495352,0.0004757509,0.00004478083,0.000005130601,0.0002653834,0.00003221927],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9985538,0.00000938353,0.0000669521,0.0001466922,0.00002685153,0.001080774,0.00000716381,0.00000438284,0.00010404],"genre_scores_gemma":[0.9997553,3.146646e-7,0.0001098438,0.00004286128,0.0000069218,0.00002487897,0.00004478475,0.000004279186,0.00001084054],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0130391,"threshold_uncertainty_score":0.1433259,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0189463547770563,"score_gpt":0.2487504831597485,"score_spread":0.2298041283826922,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}