{"id":"W4293334925","doi":"10.1016/j.jconrel.2022.08.042","title":"LNP-mediated delivery of CRISPR RNP for wide-spread in vivo genome editing in mouse cornea","year":2022,"lang":"en","type":"article","venue":"Journal of Controlled Release","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":62,"is_retracted":false,"has_abstract":true,"ca_institutions":"Incisive Genetics (Canada); BC Children's Hospital; University of British Columbia","funders":"","keywords":"Genome editing; CRISPR; Ribonucleoprotein; Cas9; Guide RNA; Computational biology; Genome; Cornea; Ex vivo; Cell biology; Biology; In vivo; RNA; Genetics; Gene; Neuroscience","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003914004,0.0003962426,0.0002640379,0.0003059428,0.0001996522,0.000318332,0.0003299548,0.0005686767,0.0009941633],"category_scores_gemma":[0.0001838384,0.0002288551,0.0003212653,0.0001471326,0.0003079682,0.0003296687,0.0003088656,0.0007317488,0.0003554823],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003856623,"about_ca_system_score_gemma":0.0004671278,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001267476,"about_ca_topic_score_gemma":0.00180291,"domain_scores_codex":[0.9997366,0.00004176721,0.00002731522,0.00007450497,0.00007199712,0.00004779226],"domain_scores_gemma":[0.9998345,0.00003362659,0.00005623907,0.00002473933,0.00002070809,0.00003013124],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002240423,0.00001493825,0.00003273879,0.00002793213,0.000002245256,0.00004406826,0.00001197984,0.0001814576,0.9986677,0.0001159657,0.00003112386,0.0008475076],"study_design_scores_gemma":[0.000005246428,0.00007073108,0.0001988119,0.000003552109,0.00000458505,0.00005911195,0.000005938307,0.001087204,0.9977118,0.00002047828,0.0008291862,0.000003311116],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9017646,0.001704456,0.089345,0.0002961295,0.000150179,0.0004160537,0.001098845,0.00091536,0.004309308],"genre_scores_gemma":[0.9475193,0.001408358,0.04389234,0.0001151067,0.00001339073,0.0003270091,0.0004798298,0.0001780673,0.006066641],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001267476,"threshold_uncertainty_score":0.00332582,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005604476592208423,"score_gpt":0.2513862389881965,"score_spread":0.2457817623959881,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}