{"id":"W4293367557","doi":"10.1002/cpdd.1153","title":"Bioequivalence and Relative Bioavailability Studies to Assess a New Acalabrutinib Formulation That Enables Coadministration With Proton‐Pump Inhibitors","year":2022,"lang":"en","type":"article","venue":"Clinical Pharmacology in Drug Development","topic":"Chronic Lymphocytic Leukemia Research","field":"Medicine","cited_by":26,"is_retracted":false,"has_abstract":true,"ca_institutions":"AstraZeneca (Canada)","funders":"","keywords":"Bioavailability; Pharmacokinetics; Medicine; Pharmacology; Tolerability; Bioequivalence; Chemistry; Adverse effect","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003150539,0.0002271638,0.0005456663,0.0001971038,0.0002532387,0.00001542006,0.0001636072,0.00009876618,0.0001972898],"category_scores_gemma":[0.0007162066,0.0001843022,0.00004310423,0.0005299061,0.0003590231,0.00016444,0.0006084793,0.0007143082,0.00001888156],"about_ca_system_candidate":true,"about_ca_system_consensus":true,"about_ca_system_score_codex":0.006628006,"about_ca_system_score_gemma":0.01032065,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006288689,"about_ca_topic_score_gemma":0.00008921944,"domain_scores_codex":[0.9967754,0.0005264098,0.0009037188,0.0007415941,0.0006028781,0.0004500318],"domain_scores_gemma":[0.9974825,0.001598623,0.0002041392,0.0001998528,0.0001629084,0.0003519682],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.01829172,0.003574937,0.8743407,0.001631671,0.001635657,0.001127161,0.03122099,0.000482438,0.004071472,0.0002611229,0.0348546,0.02850752],"study_design_scores_gemma":[0.1237467,0.008438784,0.451172,0.001042578,0.0007195319,0.0005635032,0.01603118,0.004499055,0.2250657,0.001342879,0.16527,0.002108238],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9892536,0.000260457,0.00008260399,0.005980874,0.0004331641,0.003771568,0.000004067482,0.00005308372,0.0001605279],"genre_scores_gemma":[0.992294,0.0001585017,0.003702515,0.001327247,0.0001368934,0.001159837,0.00002301397,0.00002041911,0.001177573],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4231687,"threshold_uncertainty_score":0.9971853,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2395849207718664,"score_gpt":0.4805594073694024,"score_spread":0.240974486597536,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}