{"id":"W4293393139","doi":"10.1016/j.onano.2022.100073","title":"Complex dispersions of poloxamers and mesoporous carriers with ibrutinib","year":2022,"lang":"en","type":"article","venue":"OpenNano","topic":"Chronic Lymphocytic Leukemia Research","field":"Medicine","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Research Council Canada; Ministry of Education and Science of the Russian Federation","keywords":"Poloxamer; Ibrutinib; Solubility; Mesoporous material; Mesoporous silica; Bioavailability; Dissolution; Materials science; Chemistry; Aqueous solution; Chemical engineering; Chromatography; Organic chemistry; Pharmacology; Medicine; Polymer; Copolymer","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0002021825,0.00009629688,0.0002611734,0.00008712881,0.0001845943,0.000008504216,0.0001374667,0.00002300285,0.001944064],"category_scores_gemma":[0.00003868842,0.00007537594,0.00003792306,0.000284322,0.0003413599,0.00003702923,0.000293486,0.0001599472,0.000008410835],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001698493,"about_ca_system_score_gemma":0.002551669,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001759344,"about_ca_topic_score_gemma":0.00004213642,"domain_scores_codex":[0.998834,0.00005680264,0.0001512957,0.0002316771,0.0004621689,0.0002640385],"domain_scores_gemma":[0.999311,0.00006673535,0.00005381156,0.0003385891,0.00004556835,0.0001843049],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.02993779,0.003812987,0.1715184,0.003099222,0.004809242,0.01004105,0.05327061,0.001369367,0.2711679,0.02810949,0.3480509,0.07481305],"study_design_scores_gemma":[0.1442907,0.01390445,0.05011305,0.0003955774,0.001009767,0.01124576,0.06635007,0.02171868,0.01427475,0.000187565,0.6748878,0.001621885],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9728111,0.0002833069,0.00001039024,0.001401702,0.00003808231,0.0004941152,0.00005347413,0.00002010299,0.02488772],"genre_scores_gemma":[0.9945372,0.00002833233,0.0005709334,0.0002828519,0.00001574134,0.00003007117,0.0000390256,0.00002160881,0.004474226],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3268369,"threshold_uncertainty_score":0.9989683,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02473828667088154,"score_gpt":0.2923167288196647,"score_spread":0.2675784421487832,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}