{"id":"W4293410865","doi":"10.1161/circulationaha.122.061612","title":"A Multicenter, Phase 2, Randomized, Placebo-Controlled, Double-Blind, Parallel-Group, Dose-Finding Trial of the Oral Factor XIa Inhibitor Asundexian to Prevent Adverse Cardiovascular Outcomes After Acute Myocardial Infarction","year":2022,"lang":"en","type":"article","venue":"Circulation","topic":"Coagulation, Bradykinin, Polyphosphates, and Angioedema","field":"Medicine","cited_by":148,"is_retracted":false,"has_abstract":true,"ca_institutions":"Population Health Research Institute","funders":"","keywords":"Medicine; Placebo; Myocardial infarction; Internal medicine; Aspirin; Randomization; Randomized controlled trial; Adverse effect; Percutaneous coronary intervention; Surgery; Gastroenterology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001353388,0.0003453149,0.001428399,0.0003166482,0.0003316463,0.00003793949,0.000155774,0.000133156,0.0002133323],"category_scores_gemma":[0.0002040602,0.0002648789,0.00232521,0.0004111848,0.00008040527,0.0002429648,0.0001421535,0.00027142,0.00001178537],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003970421,"about_ca_system_score_gemma":0.0001430405,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002003471,"about_ca_topic_score_gemma":0.00002364806,"domain_scores_codex":[0.9962608,0.0006313042,0.001041995,0.0005027189,0.001202309,0.0003609235],"domain_scores_gemma":[0.9984079,0.0001941167,0.0004348806,0.0006542806,0.0001300191,0.0001787951],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9698414,0.0007843145,0.0150773,0.0000343761,0.003379183,0.000009582935,0.001559826,0.005795282,0.0004737626,0.00008044746,0.00003688417,0.002927611],"study_design_scores_gemma":[0.9516009,0.0002777438,0.04035553,0.00004921706,0.0027873,0.00001556284,0.0001822366,0.003104808,0.0001423848,0.00004142789,0.001167641,0.0002752409],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.98365,0.0003122966,0.001627055,0.0005035162,0.002452839,0.0112447,0.000054897,0.00007621646,0.00007845329],"genre_scores_gemma":[0.9964638,0.00001322449,0.0001539046,0.000227979,0.0005359138,0.002182885,0.000194266,0.00004978919,0.0001781935],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02527822,"threshold_uncertainty_score":0.9999803,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03147458403091465,"score_gpt":0.3059081229783723,"score_spread":0.2744335389474576,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}