{"id":"W4293410865","doi":"10.1161/circulationaha.122.061612","title":"A Multicenter, Phase 2, Randomized, Placebo-Controlled, Double-Blind, Parallel-Group, Dose-Finding Trial of the Oral Factor XIa Inhibitor Asundexian to Prevent Adverse Cardiovascular Outcomes After Acute Myocardial Infarction","year":2022,"lang":"en","type":"article","venue":"Circulation","topic":"Coagulation, Bradykinin, Polyphosphates, and Angioedema","field":"Medicine","cited_by":148,"is_retracted":false,"has_abstract":true,"ca_institutions":"Population Health Research Institute","funders":"","keywords":"Medicine; Placebo; Myocardial infarction; Internal medicine; Aspirin; Randomization; Randomized controlled trial; Adverse effect; Percutaneous coronary intervention; Surgery; Gastroenterology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003278759,0.002255912,0.003232965,0.0004544231,0.0005919966,0.001211226,0.0008853687,0.001976127,0.00761536],"category_scores_gemma":[0.003019214,0.0009537847,0.001352599,0.0003755458,0.001214644,0.001205659,0.0004019739,0.002274063,0.001005368],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006355125,"about_ca_system_score_gemma":0.001332606,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004542746,"about_ca_topic_score_gemma":0.001133873,"domain_scores_codex":[0.9987961,0.0007457521,0.00007031952,0.0002145243,0.00006660678,0.000106667],"domain_scores_gemma":[0.9987236,0.0003399189,0.0003685229,0.0001328249,0.0001293396,0.0003058399],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9851972,0.005401931,0.0003484336,0.0003628323,0.0005345724,0.0000217182,0.000039072,0.0001444865,0.002544702,0.00007563593,0.0004628781,0.004866532],"study_design_scores_gemma":[0.9796438,0.01911515,0.0005053678,0.00001195081,0.0001970013,0.00001182426,0.000006066533,0.0001316669,0.0001601407,0.00004769395,0.0001643461,0.000005075279],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9852462,0.003389905,0.0008098498,0.0008368237,0.000726415,0.00584201,0.0009414922,0.000126769,0.002080549],"genre_scores_gemma":[0.9797782,0.002401315,0.002810304,0.001379422,0.0008029318,0.008647587,0.001216408,0.00002997047,0.002933895],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00761536,"threshold_uncertainty_score":0.02547592,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03147458403091465,"score_gpt":0.3059081229783723,"score_spread":0.2744335389474576,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}