{"id":"W4293425121","doi":"10.1002/clt2.12173","title":"Association of bronchial steroid inducible methylation quantitative trait loci with asthma and chronic obstructive pulmonary disease treatment response","year":2022,"lang":"en","type":"letter","venue":"Clinical and Translational Allergy","topic":"Neonatal Respiratory Health Research","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Paul's Hospital; University of British Columbia","funders":"National Institute on Minority Health and Health Disparities; National Institute of Environmental Health Sciences; National Institute of General Medical Sciences; National Heart, Lung, and Blood Institute; Javna Agencija za Raziskovalno Dejavnost RS; Agencia Estatal de Investigación; Genentech; Robert Wood Johnson Foundation; National Institutes of Health; Longfonds; Ministrstvo za Izobraževanje, Znanost in Šport; European Commission; Ministerio de Ciencia e Innovación; Roche Diagnostics; National Center for Advancing Translational Sciences; Leids Universitair Medisch Centrum; Universiteit Leiden; Stichting Astma Bestrijding; National Human Genome Research Institute; American Asthma Foundation; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; European Regional Development Fund; Universitair Medisch Centrum Groningen; GlaxoSmithKline; Utrechts Instituut voor Farmaceutische Wetenschappen, Departement Farmaceutische Wetenschappen, Universiteit Utrecht; Tobacco-Related Disease Research Program; Instituto de Salud Carlos III","keywords":"DNA methylation; Single-nucleotide polymorphism; Medicine; Asthma; COPD; Epigenetics; Methylation; Quantitative trait locus; Pharmacogenetics; Odds ratio; Expression quantitative trait loci; Immunology; Internal medicine; Bioinformatics; Genotype; Genetics; Gene; Biology; Gene expression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002107799,0.0004919851,0.001008243,0.0004079966,0.000418049,0.0008972141,0.0006763496,0.001529121,0.004755369],"category_scores_gemma":[0.008799523,0.0002733201,0.0004958974,0.0006900501,0.0004887077,0.0003455937,0.0004027464,0.001504818,0.0006711332],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004205961,"about_ca_system_score_gemma":0.0003441677,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002399587,"about_ca_topic_score_gemma":0.003456167,"domain_scores_codex":[0.9985824,0.0004373786,0.0002570969,0.0003675355,0.0002216838,0.0001339936],"domain_scores_gemma":[0.9927602,0.004465755,0.0009450866,0.0002386455,0.001172931,0.0004174266],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.01094903,0.0002739254,0.4876727,0.003986091,0.003021659,0.003642604,0.0006511771,0.0007763659,0.01001177,0.0005578446,0.4023375,0.07611924],"study_design_scores_gemma":[0.001128082,0.000935845,0.8460121,0.001062061,0.00206455,0.005036635,0.0007159531,0.00666946,0.005972388,0.00142061,0.1287974,0.0001848664],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.5372028,0.07714526,0.005151365,0.2717409,0.08035967,0.0001965989,0.02476335,0.0003345844,0.003105558],"genre_scores_gemma":[0.8413065,0.01204561,0.002501107,0.05227834,0.07768524,0.0002926995,0.005031315,0.000255411,0.008603855],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004755369,"threshold_uncertainty_score":0.0159083,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07810610959730925,"score_gpt":0.3862959264932374,"score_spread":0.3081898168959281,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}