{"id":"W4293425121","doi":"10.1002/clt2.12173","title":"Association of bronchial steroid inducible methylation quantitative trait loci with asthma and chronic obstructive pulmonary disease treatment response","year":2022,"lang":"en","type":"letter","venue":"Clinical and Translational Allergy","topic":"Neonatal Respiratory Health Research","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Paul's Hospital; University of British Columbia","funders":"National Institute on Minority Health and Health Disparities; National Institute of Environmental Health Sciences; National Institute of General Medical Sciences; National Heart, Lung, and Blood Institute; Javna Agencija za Raziskovalno Dejavnost RS; Agencia Estatal de Investigación; Genentech; Robert Wood Johnson Foundation; National Institutes of Health; Longfonds; Ministrstvo za Izobraževanje, Znanost in Šport; European Commission; Ministerio de Ciencia e Innovación; Roche Diagnostics; National Center for Advancing Translational Sciences; Leids Universitair Medisch Centrum; Universiteit Leiden; Stichting Astma Bestrijding; National Human Genome Research Institute; American Asthma Foundation; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; European Regional Development Fund; Universitair Medisch Centrum Groningen; GlaxoSmithKline; Utrechts Instituut voor Farmaceutische Wetenschappen, Departement Farmaceutische Wetenschappen, Universiteit Utrecht; Tobacco-Related Disease Research Program; Instituto de Salud Carlos III","keywords":"DNA methylation; Single-nucleotide polymorphism; Medicine; Asthma; COPD; Epigenetics; Methylation; Quantitative trait locus; Pharmacogenetics; Odds ratio; Expression quantitative trait loci; Immunology; Internal medicine; Bioinformatics; Genotype; Genetics; Gene; Biology; Gene expression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008956734,0.0002958386,0.0007041407,0.0002234993,0.0001606714,0.00001583477,0.00007216214,0.0004266467,0.000447493],"category_scores_gemma":[0.0003112984,0.0002393758,0.0001757509,0.0002028344,0.0003607176,0.0001239721,0.00003095317,0.00125603,0.0000026505],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002711712,"about_ca_system_score_gemma":0.001748805,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005483695,"about_ca_topic_score_gemma":0.00007280766,"domain_scores_codex":[0.9961832,0.00109391,0.000794495,0.0007020601,0.0009096659,0.0003167077],"domain_scores_gemma":[0.9953794,0.003517533,0.0003808393,0.0002063533,0.000232811,0.0002830805],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.3741918,0.003863167,0.07702599,0.006998132,0.01078035,0.004296053,0.002472562,0.0004424117,0.00122842,0.002035906,0.01531461,0.5013506],"study_design_scores_gemma":[0.004306859,0.00528224,0.350334,0.0001033636,0.0001973304,0.000021606,0.00003140354,0.0004233781,0.00001818909,0.0007632229,0.6382913,0.0002271192],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.5118973,0.01311259,0.0001670878,0.4697142,0.0002231153,0.002178873,0.002336176,0.00004528005,0.0003254398],"genre_scores_gemma":[0.8156478,0.009897455,0.005449328,0.1179167,0.008528695,0.001707258,0.01862965,0.0005783113,0.02164483],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6229767,"threshold_uncertainty_score":0.9761462,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07810610959730925,"score_gpt":0.3862959264932374,"score_spread":0.3081898168959281,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}