{"id":"W4293434050","doi":"10.1016/j.jcyt.2022.07.008","title":"Concurrent transposon engineering and CRISPR/Cas9 genome editing of primary CLL-1 chimeric antigen receptor–natural killer cells","year":2022,"lang":"en","type":"article","venue":"Cytotherapy","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":38,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"University of Galway; Science Foundation Ireland; Irish Cancer Society; Health Research Board; Health Service Executive; Wellcome Trust; Canadian Institute for Theoretical Astrophysics","keywords":"Chimeric antigen receptor; Biology; Interleukin 21; Antigen; Immunotherapy; Cancer research; Immunology; CD8; Immune system","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002751212,0.0004290981,0.0003595544,0.0002907834,0.0001823798,0.0004407249,0.000358404,0.0004396195,0.002332864],"category_scores_gemma":[0.0001952397,0.0001827072,0.0003097089,0.0001320357,0.000302907,0.0001764952,0.000444527,0.0006092228,0.0006567229],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004561624,"about_ca_system_score_gemma":0.0003873711,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007441378,"about_ca_topic_score_gemma":0.001410612,"domain_scores_codex":[0.9995406,0.00004314996,0.00003617438,0.0001370283,0.0001334695,0.0001095668],"domain_scores_gemma":[0.9998688,0.00002469155,0.00003277613,0.0000233929,0.00002042588,0.00002993733],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004696016,0.00002495379,0.0001308078,0.00003287935,0.000004421668,0.00006298135,0.00002925161,0.0001726842,0.997348,0.0002151167,0.00005977022,0.001872175],"study_design_scores_gemma":[0.00001327092,0.0001585954,0.0004648627,0.000002810471,0.00001368623,0.0002919634,0.0000138787,0.001624286,0.9941385,0.00005285219,0.003220887,0.000004466283],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9313073,0.0007823303,0.06049054,0.0001582185,0.0001280644,0.0004228618,0.0006204423,0.0009627067,0.00512745],"genre_scores_gemma":[0.9727353,0.000322013,0.01980213,0.00006574427,0.00001423377,0.0001985055,0.0005310247,0.00007243798,0.006258564],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002332864,"threshold_uncertainty_score":0.007804215,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007255950897308586,"score_gpt":0.201337743401986,"score_spread":0.1940817925046774,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}