{"id":"W4293452270","doi":"10.1128/mbio.02137-22","title":"Dual Targeting Factors Are Required for LXG Toxin Export by the Bacterial Type VIIb Secretion System","year":2022,"lang":"en","type":"article","venue":"mBio","topic":"Bacterial Genetics and Biotechnology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":39,"is_retracted":false,"has_abstract":true,"ca_institutions":"Population Health Research Institute; McMaster University","funders":"Argonne National Laboratory; Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Office of Science; Hospital for Sick Children; Government of Canada; Scheme for Promotion of Academic and Research Collaboration; U.S. Department of Energy","keywords":"Secretion; Microbiology; Toxin; Bacteria; Microbial toxins; Staphylococcus aureus; Streptococcus; Enterococcus; Biology; Bacterial protein; Biochemistry; Genetics; Antibiotics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000197587,0.0005741297,0.0003432493,0.0003443024,0.000222886,0.000896586,0.0002226589,0.0005145106,0.001984802],"category_scores_gemma":[0.000477288,0.0002315839,0.0003481162,0.0001684909,0.0002957258,0.0003954747,0.0005929738,0.0005280889,0.001338904],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005608124,"about_ca_system_score_gemma":0.0003167698,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006043029,"about_ca_topic_score_gemma":0.0006694726,"domain_scores_codex":[0.9997119,0.00004556249,0.00003437106,0.00004783039,0.00009521157,0.00006509549],"domain_scores_gemma":[0.9996586,0.00005908011,0.0001246092,0.00003120437,0.00002562694,0.0001008943],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001373831,0.00001535341,0.0009655411,0.00002940621,0.000005824265,0.0002114096,0.00002171005,0.00002525975,0.9972217,0.0001535899,0.00006576545,0.001147005],"study_design_scores_gemma":[0.00003244332,0.0001393173,0.01813255,0.00001424819,0.00001612525,0.002823832,0.0001105598,0.00134621,0.9722567,0.0002051731,0.004904856,0.0000180688],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9905195,0.001830819,0.005675186,0.0001972325,0.00004038024,0.00001796532,0.0005918456,0.0002136518,0.000913287],"genre_scores_gemma":[0.9918853,0.0003649824,0.003239542,0.00008887699,0.00001693401,0.00002361625,0.002031671,0.00007955258,0.002269526],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001984802,"threshold_uncertainty_score":0.006639838,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01266542288759877,"score_gpt":0.2200530055694767,"score_spread":0.2073875826818779,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}