{"id":"W4293462471","doi":"10.1007/s13402-022-00706-4","title":"Dual contribution of the mTOR pathway and of the metabolism of amino acids in prostate cancer","year":2022,"lang":"en","type":"review","venue":"Cellular Oncology","topic":"PI3K/AKT/mTOR signaling in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":19,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Montréal; Hôpital Maisonneuve-Rosemont","funders":"Fonds de Recherche du Québec - Santé","keywords":"Prostate cancer; PI3K/AKT/mTOR pathway; Sarcosine; Glutamine; Prostate; Cancer; Medicine; Cancer research; Amino acid; Biology; Internal medicine; Bioinformatics; Glycine; Signal transduction; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006573945,0.001139901,0.001564355,0.001976292,0.0002337125,0.001236183,0.001071453,0.001401635,0.002486874],"category_scores_gemma":[0.0006266724,0.0003229238,0.0004448953,0.00265427,0.0005988666,0.001318551,0.0008716438,0.002511922,0.001782039],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008502741,"about_ca_system_score_gemma":0.001235996,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001277572,"about_ca_topic_score_gemma":0.002580915,"domain_scores_codex":[0.9998398,0.00002398462,0.00002141248,0.00003060211,0.00006500647,0.0000192064],"domain_scores_gemma":[0.9997413,0.0001027141,0.00003895051,0.000007793141,0.0000741625,0.00003508879],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002134054,0.00008118005,0.000160269,0.01613402,0.0001238692,0.0002869778,0.00002832061,0.000562429,0.002762255,0.005174197,0.04701389,0.9274591],"study_design_scores_gemma":[0.00005178817,0.0001170079,0.0008321954,0.002422329,0.0001838606,0.001209305,0.00003609065,0.0001809749,0.0007363732,0.002790512,0.9914142,0.00002535689],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00003945495,0.9992292,0.00006724763,0.0001890629,0.000155052,0.000001357305,0.000009410116,0.000003257801,0.0003059084],"genre_scores_gemma":[0.0003021536,0.9989583,0.00009545725,0.0001344957,0.00024481,0.000002522424,0.00001624009,7.835694e-7,0.0002451637],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002486874,"threshold_uncertainty_score":0.008319438,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02210276910532492,"score_gpt":0.3011387215475962,"score_spread":0.2790359524422713,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}