{"id":"W4293463343","doi":"10.1161/circulationaha.122.061533","title":"Anticoagulation and Antiplatelet Therapy for Prevention of Venous and Arterial Thrombotic Events in Critically Ill Patients With COVID-19: COVID-PACT","year":2022,"lang":"en","type":"article","venue":"Circulation","topic":"COVID-19 Clinical Research Studies","field":"Medicine","cited_by":82,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta Hospital; University of Alberta","funders":"Eisai; ARCA Biopharma; Daiichi-Sankyo; Zora Biosciences; American Heart Association; American Thoracic Society; Intarcia Therapeutics; Ionis Pharmaceuticals; National Institutes of Health; Regeneron Pharmaceuticals; Harvard Catalyst; Alnylam Pharmaceuticals; Novo Nordisk; Vertex Pharmaceuticals; Alexion Pharmaceuticals; Servier; Bayer; CSL Behring; AstraZeneca; Bristol-Myers Squibb; Pfizer; Amgen; Bayer HealthCare; Kowa Company; Sanofi; Brigham and Women's Hospital; Janssen Research and Development; United States Agency for International Development","keywords":"Medicine; Intensive care unit; Venous thrombosis; Stroke (engine); Mechanical ventilation; Clinical endpoint; Thrombosis; Pulmonary embolism; Randomized controlled trial; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002628531,0.0006097868,0.001630235,0.0003565652,0.0003268375,0.0008066999,0.0004154361,0.0006321272,0.00297643],"category_scores_gemma":[0.003254404,0.000260741,0.0009234564,0.0003996076,0.0007047904,0.000471528,0.000423618,0.001417569,0.000234289],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004861771,"about_ca_system_score_gemma":0.00153122,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002836856,"about_ca_topic_score_gemma":0.0006856511,"domain_scores_codex":[0.998588,0.0007891661,0.0001801146,0.0001821981,0.0001309549,0.0001295641],"domain_scores_gemma":[0.9975353,0.0007573949,0.0007201781,0.0001054359,0.0001130023,0.0007687267],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.8997374,0.01269226,0.01747937,0.001541944,0.001526022,0.00005471868,0.0000813217,0.0007221592,0.003384821,0.0003307681,0.001375501,0.06107366],"study_design_scores_gemma":[0.7519045,0.2141226,0.02791463,0.0002397717,0.001240892,0.0001508521,0.0000456241,0.001075771,0.001065119,0.0003509584,0.001861074,0.0000282583],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9879181,0.007708024,0.0004313661,0.0005845296,0.0001811951,0.001554222,0.0004524694,0.0000170068,0.001153081],"genre_scores_gemma":[0.9913839,0.002799292,0.001806346,0.00082803,0.0005346123,0.001840804,0.0004990523,0.000005161458,0.0003027385],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00297643,"threshold_uncertainty_score":0.01390117,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05458983670580277,"score_gpt":0.4044379480627477,"score_spread":0.3498481113569449,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}