{"id":"W4293484054","doi":"10.1073/pnas.2112870119","title":"ER-resident STIM1/2 couples Ca <sup>2+</sup> entry by NMDA receptors to pannexin-1 activation","year":2022,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Connexins and lens biology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":33,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Hospital for Sick Children; University of Manitoba","funders":"Canadian Institutes of Health Research; Natural Sciences and Engineering Research Council of Canada; Government of Canada","keywords":"Pannexin; Cell biology; Neuroscience; NMDA receptor; Biology; Endoplasmic reticulum; Excitotoxicity; Ion channel; Receptor; Chemistry; Biophysics; Biochemistry; Gap junction","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000773368,0.0003569436,0.0002413078,0.0001012769,0.0001523867,0.000210399,0.0001342878,0.0002044367,0.001487743],"category_scores_gemma":[0.00006814976,0.0001065782,0.0002181657,0.0001076496,0.0001533318,0.0002617188,0.0002429851,0.0003168997,0.0003774071],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002694612,"about_ca_system_score_gemma":0.0001267455,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002999745,"about_ca_topic_score_gemma":0.0007065177,"domain_scores_codex":[0.999905,0.000009341561,0.000008689688,0.00001982261,0.00002464048,0.00003245856],"domain_scores_gemma":[0.9999684,0.000003773592,0.00001223935,0.000002969611,0.000004011149,0.000008477815],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003223282,0.000003908356,0.00007939596,0.00001876247,0.000001778885,0.00002991066,0.00000658932,0.00002480104,0.9994346,0.00004942442,0.00001455089,0.0003038947],"study_design_scores_gemma":[0.000007854329,0.00005885289,0.005576665,0.000004077342,0.000007206005,0.0002715127,0.00002277277,0.0007659356,0.9915902,0.00003776436,0.001654231,0.000002979541],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9961535,0.0007677987,0.001580922,0.00008659353,0.00001433183,0.00001579525,0.0001627669,0.00003896211,0.001179139],"genre_scores_gemma":[0.9942976,0.001183307,0.001863475,0.00008371002,0.0000121095,0.00003628257,0.0003247338,0.00001599231,0.002182948],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001487743,"threshold_uncertainty_score":0.004976988,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01997694143005133,"score_gpt":0.2781642016281952,"score_spread":0.2581872601981439,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}