{"id":"W4293484211","doi":"10.1073/pnas.2203452119","title":"3D chromatin remodeling potentiates transcriptional programs driving cell invasion","year":2022,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Genomics and Chromatin Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; McGill University Health Centre; Institute for Research in Immunology and Cancer; University of British Columbia; McGill University; Jewish General Hospital","funders":"Canadian Institutes of Health Research","keywords":"CTCF; Chromatin; Enhancer; Histone; Chromatin remodeling; Biology; Cell biology; ChIA-PET; Epigenetics; Epigenome; Histone code; Histone-modifying enzymes; Bivalent chromatin; Genetics; Transcription factor; Cancer research; Gene; Gene expression; DNA methylation; Nucleosome","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001041121,0.0001131884,0.00011914,0.0001267434,0.0001200105,0.0003518136,0.0001221899,0.0001613415,0.002014022],"category_scores_gemma":[0.0001412728,0.000151544,0.0001547224,0.00005867407,0.0002485401,0.00009333193,0.0003571121,0.0003197647,0.0003823549],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002739702,"about_ca_system_score_gemma":0.0001144637,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000469845,"about_ca_topic_score_gemma":0.001208905,"domain_scores_codex":[0.9999098,0.00001277124,0.000003938523,0.00001743059,0.00002790048,0.00002825775],"domain_scores_gemma":[0.9998877,0.00002095704,0.00003014621,0.00001724965,0.00000835029,0.00003552207],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007087395,0.00001312719,0.0003197997,0.00001197074,0.000002897596,0.00003870786,0.000009317338,0.0001399441,0.9983504,0.0001628875,0.0000464512,0.0008336458],"study_design_scores_gemma":[0.00002909923,0.0001831153,0.01684444,0.000006371481,0.00001117515,0.0003505523,0.00005112937,0.003744197,0.974609,0.0002569518,0.003906676,0.000007357277],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9955447,0.0003112164,0.001582931,0.0001049735,0.00001711532,0.000006782226,0.0001131531,0.00008215988,0.002237123],"genre_scores_gemma":[0.998403,0.0000768117,0.0004469196,0.00003917146,0.000004775685,0.000006012469,0.0001183717,0.00001114438,0.000893693],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002014022,"threshold_uncertainty_score":0.00673753,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02146942597391033,"score_gpt":0.245519896098535,"score_spread":0.2240504701246247,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}