{"id":"W4293536269","doi":"10.1101/2022.08.29.505317","title":"Histone variant H2A.Z modulates nucleosome dynamics to promote DNA accessibility","year":2022,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Genomics and Chromatin Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"Natural Sciences and Engineering Research Council of Canada; Queen's University; Compute Canada","keywords":"Nucleosome; Histone; Chromatin; DNA; Genetics; Biology; Linker DNA; HMG-box; Histone methylation; DNA repair; Biophysics; Base pair; Cell biology; Chemistry; Transcription factor; Gene; DNA-binding protein; DNA methylation; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001132107,0.00018901,0.0001398956,0.00008625023,0.0001137808,0.0002887724,0.000268217,0.000157182,0.001571548],"category_scores_gemma":[0.0001385369,0.0001048788,0.0001706232,0.0000916337,0.0001592206,0.0001584429,0.000182733,0.000205141,0.0003500586],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002126638,"about_ca_system_score_gemma":0.000142268,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001539624,"about_ca_topic_score_gemma":0.001387784,"domain_scores_codex":[0.9999496,0.000006823144,0.000002439614,0.00001430516,0.00001475497,0.00001209859],"domain_scores_gemma":[0.9999495,0.0000124926,0.0000120189,0.000006158215,0.000008342933,0.00001152079],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002111517,0.00002256867,0.002204875,0.00003933569,0.000019686,0.00003987611,0.00001207487,0.0021992,0.9933987,0.0003040037,0.00009688745,0.001451722],"study_design_scores_gemma":[0.00003290785,0.0001091284,0.008565627,0.000006019158,0.00002379577,0.00006701636,0.00004165778,0.02561641,0.9641085,0.0002532243,0.001163128,0.0000126964],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9932083,0.0004346304,0.005074463,0.00005887628,0.00002000271,0.000005931358,0.0001958555,0.00007944005,0.0009225042],"genre_scores_gemma":[0.9989167,0.00009810401,0.000563412,0.00001072877,0.000002074283,0.000001857038,0.00008742369,0.00001181714,0.0003078641],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001571548,"threshold_uncertainty_score":0.005257308,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0075191272637011,"score_gpt":0.2276564108172467,"score_spread":0.2201372835535456,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}