{"id":"W4293554017","doi":"10.7554/elife.80774","title":"Hypoxia-inducible factor underlies von Hippel-Lindau disease stigmata","year":2022,"lang":"en","type":"article","venue":"eLife","topic":"Cancer, Hypoxia, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":39,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Canadian Institutes of Health Research","keywords":"Hypoxia-inducible factors; Phenotype; Disease; Cancer research; Biology; Ubiquitin ligase; Von Hippel–Lindau disease; Proteasome; Genetics; Ubiquitin; Medicine; Internal medicine; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001292591,0.0001924894,0.0001969366,0.0003049922,0.000424304,0.0003693357,0.0001807825,0.0005005636,0.0009216817],"category_scores_gemma":[0.0003321049,0.00007635639,0.0001079315,0.0001829966,0.0006437761,0.0002745732,0.0004670789,0.0003468321,0.0002154065],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005723605,"about_ca_system_score_gemma":0.0003570661,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009641153,"about_ca_topic_score_gemma":0.001877756,"domain_scores_codex":[0.9999009,0.0000118775,0.000006336936,0.00002773583,0.00002871427,0.00002442816],"domain_scores_gemma":[0.9998565,0.00002585349,0.00005664898,0.00001036252,0.000017171,0.0000335076],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008529918,0.0001818386,0.07712667,0.0008031071,0.0001453057,0.1585736,0.00170119,0.001420731,0.6233101,0.04025343,0.009964532,0.08566654],"study_design_scores_gemma":[0.0001266213,0.0005696116,0.1992551,0.0002948263,0.0002013553,0.3915095,0.001807896,0.007576956,0.2374607,0.03291103,0.1281866,0.00009997113],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.966614,0.01481596,0.003585187,0.003257601,0.0002223448,0.00003322209,0.0002494077,0.0001300012,0.01109218],"genre_scores_gemma":[0.9926399,0.003747132,0.0007151304,0.0003021751,0.00009995687,0.000005011977,0.00008630605,0.00001153682,0.002392816],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009641153,"threshold_uncertainty_score":0.004152715,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02049484721664284,"score_gpt":0.2586555406289254,"score_spread":0.2381606934122826,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}