{"id":"W4293560769","doi":"10.1002/acr.25007","title":"Update on the Efficacy and Safety Profile of Voclosporin: An Integrated Analysis of Clinical Trials in Lupus Nephritis","year":2022,"lang":"en","type":"article","venue":"Arthritis Care & Research","topic":"Systemic Lupus Erythematosus Research","field":"Medicine","cited_by":46,"is_retracted":false,"has_abstract":true,"ca_institutions":"Aurinia (Canada)","funders":"Daiichi Sankyo Europe; EMD Serono; Genentech; Chugai Pharmaceutical; Mitsubishi Tanabe Pharma Corporation; Astellas Pharma; Eisai; Alexion Pharmaceuticals; GlaxoSmithKline; AstraZeneca; Eli Lilly and Company; Bristol-Myers Squibb; National Institute of Diabetes and Digestive and Kidney Diseases; Johns Hopkins University; Vifor Pharma; Pfizer; Gilead Sciences; Eli Lilly Japan; National Institutes of Health; Lupus Foundation of America; American Society of Nephrology","keywords":"Lupus nephritis; Clinical trial; Medicine; Systemic lupus erythematosus; Safety profile; Internal medicine; Immunology; Adverse effect; Disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaresearch","insufficient_payload"],"consensus_categories":["metaresearch"],"category_scores_codex":[0.03365352,0.0001794131,0.002003753,0.001448908,0.0002249653,0.00003049135,0.0004762257,0.0001427393,0.001585581],"category_scores_gemma":[0.0104003,0.0001294975,0.0003882817,0.004151595,0.0006513098,0.00007140169,0.0004717528,0.001600442,0.00001279675],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002018169,"about_ca_system_score_gemma":0.0007329477,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001091949,"about_ca_topic_score_gemma":0.001044731,"domain_scores_codex":[0.9824138,0.01175118,0.002289528,0.0006553245,0.002310526,0.0005796724],"domain_scores_gemma":[0.9890995,0.008219798,0.0003220099,0.001120572,0.0009684763,0.0002696484],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"qualitative","study_design_scores_codex":[0.008631839,0.001085704,0.644812,0.0003985099,0.001149924,0.0005129411,0.01069298,0.00005195013,0.001103632,0.002512673,0.003186426,0.3258614],"study_design_scores_gemma":[0.06882412,0.02250759,0.406189,0.005602757,0.001030224,0.002294955,0.4250102,0.005766778,0.006195352,0.0004045154,0.05507297,0.001101519],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9895424,0.004998541,0.00000376382,0.0009721972,0.0001537719,0.002431966,0.0004923225,0.0000207852,0.001384202],"genre_scores_gemma":[0.9962814,0.002606688,0.00009197785,0.00005241834,0.0000853875,0.0002889285,0.0002958545,0.00003425526,0.0002631286],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4143173,"threshold_uncertainty_score":0.9993271,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1589623984727818,"score_gpt":0.4741238334489187,"score_spread":0.3151614349761369,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}