{"id":"W4293560769","doi":"10.1002/acr.25007","title":"Update on the Efficacy and Safety Profile of Voclosporin: An Integrated Analysis of Clinical Trials in Lupus Nephritis","year":2022,"lang":"en","type":"article","venue":"Arthritis Care & Research","topic":"Systemic Lupus Erythematosus Research","field":"Medicine","cited_by":46,"is_retracted":false,"has_abstract":true,"ca_institutions":"Aurinia (Canada)","funders":"Daiichi Sankyo Europe; EMD Serono; Genentech; Chugai Pharmaceutical; Mitsubishi Tanabe Pharma Corporation; Astellas Pharma; Eisai; Alexion Pharmaceuticals; GlaxoSmithKline; AstraZeneca; Eli Lilly and Company; Bristol-Myers Squibb; National Institute of Diabetes and Digestive and Kidney Diseases; Johns Hopkins University; Vifor Pharma; Pfizer; Gilead Sciences; Eli Lilly Japan; National Institutes of Health; Lupus Foundation of America; American Society of Nephrology","keywords":"Lupus nephritis; Clinical trial; Medicine; Systemic lupus erythematosus; Safety profile; Internal medicine; Immunology; Adverse effect; Disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.06366188,0.00182249,0.007380744,0.005367744,0.0006019186,0.006549182,0.002194142,0.002950697,0.002304222],"category_scores_gemma":[0.08667289,0.001171276,0.007566624,0.006572454,0.0007536954,0.003120048,0.001931223,0.004016429,0.0006690227],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.003428118,"about_ca_system_score_gemma":0.005095366,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002546076,"about_ca_topic_score_gemma":0.008203701,"domain_scores_codex":[0.957903,0.01968742,0.008028641,0.0022073,0.01138795,0.0007857713],"domain_scores_gemma":[0.7997085,0.1032054,0.04415061,0.006658652,0.04205501,0.004221721],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"meta_analysis","study_design_scores_codex":[0.0219276,0.0004362258,0.01245408,0.05172846,0.05308189,0.0002257001,0.0003927847,0.002369339,0.007484651,0.001993417,0.06656088,0.781345],"study_design_scores_gemma":[0.02116484,0.01322128,0.1361046,0.04283383,0.1923159,0.00143545,0.0003247689,0.005316413,0.004869635,0.005492958,0.5764683,0.0004520733],"study_design_candidate":"meta_analysis","study_design_consensus":null,"genre_codex":"review","genre_gemma":"empirical","genre_scores_codex":[0.03687946,0.8853032,0.01801326,0.03087923,0.004665862,0.002242106,0.0100165,0.001038718,0.01096162],"genre_scores_gemma":[0.3066647,0.536694,0.05731367,0.04715152,0.02100613,0.003301053,0.0209483,0.001009362,0.005911177],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.06366188,"threshold_uncertainty_score":0.3366803,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1589623984727818,"score_gpt":0.4741238334489187,"score_spread":0.3151614349761369,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}