{"id":"W4293568782","doi":"10.1016/j.virol.2022.08.015","title":"Characterisation of a Seneca Valley virus thermostable mutant","year":2022,"lang":"en","type":"article","venue":"Virology","topic":"Viral Infections and Immunology Research","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University","funders":"","keywords":"Capsid; Mutant; Biology; Picornavirus; Oncolytic virus; Virus; Virology; Mutation; Strain (injury); Computational biology; Biochemistry; RNA; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001714773,0.000459712,0.0003581902,0.000297033,0.0002251066,0.0004077371,0.0003909323,0.0004268955,0.002032018],"category_scores_gemma":[0.0004022231,0.0001757054,0.0006240933,0.0002957473,0.0002796942,0.0001838004,0.000337664,0.0008326588,0.0006709785],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002230711,"about_ca_system_score_gemma":0.0002440657,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002045323,"about_ca_topic_score_gemma":0.001280988,"domain_scores_codex":[0.9998401,0.00002993099,0.00002559106,0.0000277631,0.00004302383,0.0000334302],"domain_scores_gemma":[0.9996414,0.0001042516,0.00008775785,0.00004631081,0.00005478125,0.0000654603],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007565244,0.00002933443,0.0002411355,0.00001947124,0.000009770207,0.0001102352,0.00002756627,0.0000726641,0.9987935,0.00005191069,0.00002553761,0.0005433357],"study_design_scores_gemma":[0.00003041141,0.0004668751,0.00772226,0.00001317118,0.00004156826,0.001328519,0.0001688819,0.001357245,0.9858731,0.00005080378,0.002925253,0.00002180456],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9952124,0.0002024938,0.002864681,0.00008789001,0.00003849849,0.00004081808,0.0007999513,0.00005094364,0.0007022332],"genre_scores_gemma":[0.9922497,0.0001574751,0.002842279,0.00005029291,0.00001010743,0.00004234159,0.001675301,0.0000896604,0.002882933],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002045323,"threshold_uncertainty_score":0.006797731,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02400715304347664,"score_gpt":0.2912881039235379,"score_spread":0.2672809508800613,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}