{"id":"W4293572277","doi":"10.1182/blood.2022016410","title":"Hypoxia and low temperature upregulate transferrin to induce hypercoagulability at high altitude","year":2022,"lang":"en","type":"article","venue":"Blood","topic":"High Altitude and Hypoxia","field":"Biochemistry, Genetics and Molecular Biology","cited_by":71,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canadian Blood Services; University of Toronto; St. Michael's Hospital","funders":"","keywords":"Transferrin; Hypoxia (environmental); Thrombin; Downregulation and upregulation; Thrombomodulin; Transferrin receptor; Internal medicine; Immunology; Endocrinology; Chemistry; Pharmacology; Biology; Medicine; Biochemistry; Platelet; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001665823,0.000181806,0.0001801243,0.0000358969,0.0003038807,0.00002486149,0.0002185028,0.0001148456,0.0001449507],"category_scores_gemma":[0.0000196254,0.0001847151,0.00006609336,0.000113824,0.00004717757,0.000003705728,0.0003538754,0.0001616543,0.0000128607],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001909906,"about_ca_system_score_gemma":0.00004855659,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005735154,"about_ca_topic_score_gemma":0.0001783608,"domain_scores_codex":[0.9987344,0.00009060337,0.0001700878,0.000536262,0.0001837464,0.000284882],"domain_scores_gemma":[0.999324,0.00000758762,0.00002153082,0.0004390712,0.00003366332,0.0001741835],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008333808,0.0002775258,0.005501587,0.00002047705,0.0000676632,0.00001502916,0.00009979393,0.000063705,0.992845,0.00007184263,0.0007906431,0.0001633904],"study_design_scores_gemma":[0.001914633,0.0006713963,0.1134011,0.000006656605,0.00007542251,0.0001117154,0.00004337569,0.00000178033,0.8536637,0.00005667054,0.02964886,0.0004046143],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9981802,0.0006474413,0.000004076397,0.0004170686,0.000107103,0.0003074509,0.0001241788,0.00002327078,0.000189181],"genre_scores_gemma":[0.9974779,0.00004171616,0.0002772334,0.0008414534,0.0001507517,0.0000908611,0.0001266946,0.00002743574,0.0009658898],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1391813,"threshold_uncertainty_score":0.7532462,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006368878211548705,"score_gpt":0.2110415449489088,"score_spread":0.2046726667373601,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}