{"id":"W4293572277","doi":"10.1182/blood.2022016410","title":"Hypoxia and low temperature upregulate transferrin to induce hypercoagulability at high altitude","year":2022,"lang":"en","type":"article","venue":"Blood","topic":"High Altitude and Hypoxia","field":"Biochemistry, Genetics and Molecular Biology","cited_by":71,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canadian Blood Services; University of Toronto; St. Michael's Hospital","funders":"","keywords":"Transferrin; Hypoxia (environmental); Thrombin; Downregulation and upregulation; Thrombomodulin; Transferrin receptor; Internal medicine; Immunology; Endocrinology; Chemistry; Pharmacology; Biology; Medicine; Biochemistry; Platelet; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00005420308,0.0001646884,0.0001450639,0.00007972127,0.000104502,0.0001279651,0.00007539761,0.000137297,0.0007767736],"category_scores_gemma":[0.00005741348,0.00005621009,0.0001525651,0.00005488567,0.0001379307,0.00009630148,0.0001345395,0.0002588881,0.0001058156],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001494477,"about_ca_system_score_gemma":0.0001065266,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000525985,"about_ca_topic_score_gemma":0.0007928421,"domain_scores_codex":[0.9999446,0.00001193981,0.000003240682,0.00001069227,0.00001290437,0.00001666706],"domain_scores_gemma":[0.9999626,0.000003493318,0.00001433486,0.000002877079,0.000004871427,0.00001190831],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001876339,0.00002217486,0.0002505055,0.00004934184,0.000005921843,0.00004101133,0.00001320579,0.00002368518,0.9982339,0.0000642928,0.00005412984,0.00105415],"study_design_scores_gemma":[0.00007138142,0.001466944,0.0423809,0.00002156253,0.0000477848,0.000661161,0.0000746869,0.00112537,0.9472914,0.000160675,0.006684428,0.00001366943],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9908076,0.004311142,0.003326334,0.0001752286,0.00006111148,0.00002820714,0.0001350369,0.00004364213,0.001111747],"genre_scores_gemma":[0.9969213,0.000899279,0.0009057484,0.00006439284,0.00001446568,0.0000275485,0.0001043002,0.000005185933,0.001057773],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007767736,"threshold_uncertainty_score":0.002598524,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006368878211548705,"score_gpt":0.2110415449489088,"score_spread":0.2046726667373601,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}