{"id":"W4293581699","doi":"10.1016/j.molmet.2022.101585","title":"SORLA mediates endocytic uptake of proIAPP and protects against islet amyloid deposition","year":2022,"lang":"en","type":"article","venue":"Molecular Metabolism","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Children's Hospital; University of British Columbia","funders":"Steno Diabetes Center Aarhus; Breakthrough T1D Canada; Canadian Institutes of Health Research; Juvenile Diabetes Research Foundation Canada; H2020 European Research Council; Novo Nordisk Fonden; Alzheimer Forschung Initiative","keywords":"Endocytic cycle; Islet; Amyloid (mycology); Cell biology; Chemistry; Diabetes mellitus; Endocrinology; Neuroscience; Endocytosis; Biology; Biochemistry; Cell","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001659345,0.0001635242,0.0003264133,0.0001347783,0.0001361373,0.00001436535,0.00008056266,0.00002826354,0.00007609592],"category_scores_gemma":[0.00006894259,0.0001451591,0.0001148072,0.000251693,0.00008242481,0.00005216311,0.0001334667,0.0002041512,0.000009397356],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004110708,"about_ca_system_score_gemma":0.0001921597,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003928051,"about_ca_topic_score_gemma":7.268534e-7,"domain_scores_codex":[0.998377,0.0001468619,0.0002290712,0.0002909921,0.0006496831,0.0003063872],"domain_scores_gemma":[0.9992961,0.00001746147,0.00008483016,0.0002762929,0.00007895064,0.0002463693],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001292972,0.002133853,0.00143963,0.0005383481,0.009413319,0.004051982,0.0008536685,0.00006608302,0.9455953,0.002734411,0.0002280131,0.03165241],"study_design_scores_gemma":[0.01347114,0.001002952,0.03228256,0.0001122913,0.00233287,0.0004083246,0.0005418066,0.0009924814,0.9401082,0.00211646,0.006082627,0.0005482399],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9648606,0.03267693,0.0001122725,0.0002775724,0.00004805618,0.001278028,0.0000676465,0.00004167192,0.0006372447],"genre_scores_gemma":[0.9976602,0.0002016269,0.001129307,0.0002592415,0.00004165726,0.000504868,0.0001505012,0.00003323894,0.00001938494],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0327996,"threshold_uncertainty_score":0.5919418,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01130400940016493,"score_gpt":0.259726061382431,"score_spread":0.2484220519822661,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}