{"id":"W4293581699","doi":"10.1016/j.molmet.2022.101585","title":"SORLA mediates endocytic uptake of proIAPP and protects against islet amyloid deposition","year":2022,"lang":"en","type":"article","venue":"Molecular Metabolism","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Children's Hospital; University of British Columbia","funders":"Steno Diabetes Center Aarhus; Breakthrough T1D Canada; Canadian Institutes of Health Research; Juvenile Diabetes Research Foundation Canada; H2020 European Research Council; Novo Nordisk Fonden; Alzheimer Forschung Initiative","keywords":"Endocytic cycle; Islet; Amyloid (mycology); Cell biology; Chemistry; Diabetes mellitus; Endocrinology; Neuroscience; Endocytosis; Biology; Biochemistry; Cell","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000236976,0.0005401475,0.0004712687,0.0002355056,0.0001452314,0.0005155892,0.0003343003,0.000387891,0.002590186],"category_scores_gemma":[0.0001807132,0.0001659195,0.000543777,0.0001027621,0.0002927395,0.0003672632,0.0002804085,0.0008964096,0.001199352],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002160376,"about_ca_system_score_gemma":0.0002128622,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001395156,"about_ca_topic_score_gemma":0.0001557036,"domain_scores_codex":[0.9998075,0.00002825341,0.00001975007,0.00004312566,0.00004018262,0.00006121062],"domain_scores_gemma":[0.9997298,0.00002079394,0.00008565554,0.00002782383,0.00003869172,0.00009715963],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003653394,0.00005150016,0.0002586864,0.00007033574,0.00001067157,0.0000606432,0.000009042313,0.00003651525,0.9980836,0.00005341342,0.00006346177,0.0009367157],"study_design_scores_gemma":[0.00009700833,0.001076589,0.008809143,0.0000203059,0.00006109032,0.000712311,0.00007941342,0.001093025,0.9843279,0.00006880384,0.003644718,0.000009598487],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.99189,0.002480322,0.00333806,0.0001494094,0.00005835536,0.00002901401,0.0004240538,0.0002025706,0.001428166],"genre_scores_gemma":[0.9919362,0.001370086,0.001914825,0.0001077785,0.00003478624,0.0000469873,0.0009887946,0.00004376725,0.003556944],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002590186,"threshold_uncertainty_score":0.008665025,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01130400940016493,"score_gpt":0.259726061382431,"score_spread":0.2484220519822661,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}