{"id":"W4293591925","doi":"10.1007/s00401-022-02477-6","title":"Spatiotemporal characterization of cellular tau pathology in the human locus coeruleus–pericoerulear complex by three-dimensional imaging","year":2022,"lang":"en","type":"article","venue":"Acta Neuropathologica","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":67,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ontario Brain Institute; Occupational Cancer Research Centre; University of Toronto; University Health Network; McGill University","funders":"National Research, Development and Innovation Office; Stiftelsen Lars Hiertas Minne; Åhlén-stiftelsen; Demensförbundet; Vetenskapsrådet; Stiftelsen Olle Engkvist Byggmästare; Knut och Alice Wallenbergs Stiftelse; Nemzeti Kutatási Fejlesztési és Innovációs Hivatal; Karolinska Institutet; Rossy Foundation; Edmond J. Safra Philanthropic Foundation; Hjärnfonden","keywords":"Locus coeruleus; Cytoarchitecture; Neuroscience; Biology; Neurofibrillary tangle; Pathology; Forebrain; Dendritic spine; Cerebellum; Alzheimer's disease; Hippocampal formation; Anatomy; Central nervous system; Medicine; Senile plaques; Disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001057877,0.0001429242,0.0001158113,0.0005885527,0.0002011566,0.0003698356,0.0001597927,0.0002540341,0.0005032904],"category_scores_gemma":[0.00009455634,0.0001531357,0.0001880461,0.0002338846,0.0001715962,0.0001495596,0.0002060982,0.0002486935,0.0001984077],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002313032,"about_ca_system_score_gemma":0.0001088933,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002242652,"about_ca_topic_score_gemma":0.003093109,"domain_scores_codex":[0.9999467,0.000004037158,0.000003415259,0.00001243388,0.00001967311,0.00001363716],"domain_scores_gemma":[0.9999152,0.00001388101,0.00002282723,0.00001062009,0.00002219529,0.00001515237],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.00003991771,0.00001099556,0.001592412,0.00002188128,0.000007399112,0.00009153328,0.00007283493,0.0001778975,0.9962385,0.00008051373,0.00003273786,0.001633389],"study_design_scores_gemma":[0.00001858461,0.0001742156,0.2624891,0.00002641083,0.00007307677,0.002922827,0.0003818352,0.02097294,0.7083805,0.0004177382,0.004092073,0.00005079172],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9830102,0.0008489611,0.01417894,0.00004226011,0.000007400371,0.00003048346,0.0005735807,0.0001148252,0.001193432],"genre_scores_gemma":[0.9836816,0.0005869398,0.01401745,0.00002342836,0.000005553712,0.00005173522,0.0005858272,0.00004153769,0.001006085],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002242652,"threshold_uncertainty_score":0.004459143,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03383216274807491,"score_gpt":0.2851167073915113,"score_spread":0.2512845446434364,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}