{"id":"W4293661581","doi":"10.3389/fphar.2022.945545","title":"The role of in vitro testing in pharmacovigilance for ß-lactam-induced serum sickness-like reaction: A pilot study","year":2022,"lang":"en","type":"article","venue":"Frontiers in Pharmacology","topic":"Drug-Induced Adverse Reactions","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"Canadian Institutes of Health Research","keywords":"Medicine; Pharmacovigilance; Culprit; Drug; Drug allergy; Pharmacology; Antibiotics; Adverse drug reaction; Internal medicine; Chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001116543,0.0002084235,0.0005473922,0.0005748511,0.0001966305,0.000006042258,0.0002733873,0.00004535097,0.000009432758],"category_scores_gemma":[0.0001555188,0.000205199,0.00005955656,0.00121719,0.00007087266,0.0001323832,0.000144263,0.0009832367,0.000001761754],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009775404,"about_ca_system_score_gemma":0.0003774006,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000299301,"about_ca_topic_score_gemma":0.00009005809,"domain_scores_codex":[0.9976993,0.0003926936,0.0006347037,0.0004423568,0.000267205,0.0005636968],"domain_scores_gemma":[0.9987893,0.0005557903,0.0002609261,0.000232591,0.00007875659,0.0000826046],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.002360001,0.003208016,0.09202424,0.00003968216,0.0001348963,0.0001374857,0.0009141346,0.0005551429,0.8494717,0.000007919065,0.0006368343,0.05050988],"study_design_scores_gemma":[0.07832546,0.004920514,0.3480673,0.0001091294,0.0009520073,0.0003880927,0.08123896,0.05834835,0.2635708,0.001299115,0.1614455,0.001334806],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9900404,0.0003197039,0.00001817412,0.0007430337,0.00399963,0.002678075,0.00002945079,0.00004990253,0.002121692],"genre_scores_gemma":[0.9969072,0.00002798297,0.0005695434,0.0003483237,0.0001697483,0.001729621,0.00001143156,0.00004222052,0.000193921],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.585901,"threshold_uncertainty_score":0.8367774,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03649789392941934,"score_gpt":0.326433361979334,"score_spread":0.2899354680499147,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}