{"id":"W4293694664","doi":"10.1101/gr.276409.121","title":"Mosaic loss of Chromosome Y in aged human microglia","year":2022,"lang":"en","type":"article","venue":"Genome Research","topic":"Neuroinflammation and Neurodegeneration Mechanisms","field":"Neuroscience","cited_by":39,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"National Institute of Neurological Disorders and Stroke; National Institute on Aging; National Institutes of Health; Natural Sciences and Engineering Research Council of Canada; Canadian Institute for Advanced Research","keywords":"Microglia; Biology; Pseudoautosomal region; Gene; Cell type; Pathogenesis; X chromosome; Genetics; Cell; Immunology; Inflammation","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001325523,0.0001516545,0.0002403083,0.0006133853,0.0002329603,0.000263409,0.00007360966,0.0001714747,0.0004563947],"category_scores_gemma":[0.0003069177,0.0001207304,0.0001620407,0.0004162103,0.0001533125,0.00007846153,0.0002535409,0.0001323566,0.0001824805],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001085941,"about_ca_system_score_gemma":0.0001039614,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007076829,"about_ca_topic_score_gemma":0.001171937,"domain_scores_codex":[0.9998602,0.00001605178,0.00001162276,0.0000477916,0.00003516486,0.00002912229],"domain_scores_gemma":[0.9998868,0.00002231108,0.00004208241,0.00001997528,0.00001176561,0.00001708426],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0007172425,0.00001817574,0.03720053,0.00003843641,0.00006367346,0.001342701,0.0001769102,0.0001926856,0.9539143,0.00009126284,0.00009663541,0.006147378],"study_design_scores_gemma":[0.00006083553,0.0005478086,0.8202674,0.00002401297,0.0001527465,0.01249384,0.0004153502,0.00139362,0.1603762,0.0005878822,0.003649547,0.0000306491],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9986205,0.0004448826,0.0004723766,0.000009946012,0.000002058054,0.000004381689,0.0003155347,0.000007309334,0.0001229319],"genre_scores_gemma":[0.9977549,0.0003929953,0.0007180299,0.00002233064,0.000004550845,0.00001267657,0.0008611927,0.000006122179,0.0002272537],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007076829,"threshold_uncertainty_score":0.001526773,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1242830662161292,"score_gpt":0.3662347754248161,"score_spread":0.2419517092086869,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}