{"id":"W4293718623","doi":"10.1016/j.jbc.2022.102439","title":"A previously uncharacterized O-glycopeptidase from Akkermansia muciniphila requires the Tn-antigen for cleavage of the peptide bond","year":2022,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Glycosylation and Glycoproteins Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":32,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; University of Alberta; University of Victoria","funders":"National Institute of General Medical Sciences; Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Michael Smith Health Research BC","keywords":"Akkermansia muciniphila; Mucin; Biochemistry; Biology; Akkermansia; Serine; Enzyme; Microbiology; Chemistry; Gut flora","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007056433,0.0003144455,0.0001901109,0.00009874445,0.0001702514,0.0002515633,0.0002125048,0.0003237039,0.0004812452],"category_scores_gemma":[0.0001360522,0.00006409129,0.0004300954,0.0002366445,0.0001757097,0.0002375116,0.0001633625,0.0004641232,0.0002509546],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001946247,"about_ca_system_score_gemma":0.0002039782,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007425698,"about_ca_topic_score_gemma":0.0005707404,"domain_scores_codex":[0.9999365,0.00000532459,0.000005913873,0.00001939752,0.00002020326,0.00001267968],"domain_scores_gemma":[0.9999138,0.0000143732,0.00003312077,0.000006431098,0.00001157674,0.00002068824],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002450405,0.00005368605,0.003458802,0.000162996,0.00001715543,0.000892352,0.00007150986,0.0002436854,0.9886722,0.0002852808,0.00007435607,0.005822874],"study_design_scores_gemma":[0.00003643226,0.0007983087,0.07848047,0.00003930084,0.00009519283,0.005746233,0.0003528529,0.003685766,0.8979921,0.0004530722,0.01228616,0.00003409053],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.995262,0.00116356,0.00246615,0.0001196132,0.00003769088,0.00001641447,0.0002832589,0.00002793908,0.0006232334],"genre_scores_gemma":[0.9905295,0.0007740962,0.005707571,0.00007820502,0.00002149082,0.00001430662,0.001270947,0.00001124471,0.001592667],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007425698,"threshold_uncertainty_score":0.001609921,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02629984729269561,"score_gpt":0.2751628605832797,"score_spread":0.2488630132905841,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}