{"id":"W4293720756","doi":"10.1016/j.phytochem.2022.113422","title":"A lesion-mimic mutant of Catharanthus roseus accumulates the opioid agonist, akuammicine","year":2022,"lang":"en","type":"article","venue":"Phytochemistry","topic":"Alkaloids: synthesis and pharmacology","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Brock University; University of Toronto; McGill University","funders":"","keywords":"Catharanthus roseus; Mutant; Biology; Vindoline; Biochemistry; Ethyl methanesulfonate; Biosynthesis; Wild type; Complementation; Gene; Genetics; Vinblastine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006668243,0.0004771074,0.0002295754,0.0002359339,0.00014717,0.0001703324,0.0002816764,0.0002965627,0.001069438],"category_scores_gemma":[0.00009792164,0.000152904,0.0003107942,0.0001443748,0.0001292402,0.0001105134,0.000240026,0.0003680524,0.0004894452],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002708634,"about_ca_system_score_gemma":0.0001633759,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001969411,"about_ca_topic_score_gemma":0.001921485,"domain_scores_codex":[0.9998722,0.00001840621,0.00001747183,0.00002875169,0.00004127864,0.00002182617],"domain_scores_gemma":[0.9998267,0.00002577527,0.00005513568,0.00002870146,0.00001461889,0.00004892359],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000188451,0.000005191756,0.00003817808,0.000005536313,0.000001165712,0.0000322178,0.000003746003,0.0000172113,0.999723,0.00001303451,0.000005214199,0.0001365173],"study_design_scores_gemma":[0.000009225913,0.0001833133,0.008008794,0.000004744548,0.00001193726,0.0005148523,0.0000390294,0.001545295,0.9882461,0.00002912109,0.001397932,0.000009721394],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.995141,0.0002921327,0.002150462,0.00008431157,0.00001620122,0.00002789854,0.0009181268,0.0002393125,0.001130454],"genre_scores_gemma":[0.9919784,0.0001951104,0.002897483,0.00003391908,0.000005558306,0.00002991508,0.001298964,0.00008510545,0.003475547],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001969411,"threshold_uncertainty_score":0.003915846,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.113718886561273,"score_gpt":0.4196911885641362,"score_spread":0.3059723020028632,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}