{"id":"W4293733615","doi":"10.3390/molecules27175552","title":"Dual Inhibition of HIV-1 and Cathepsin L Proteases by Sarcandra glabra","year":2022,"lang":"en","type":"article","venue":"Molecules","topic":"Biochemical and Structural Characterization","field":"Biochemistry, Genetics and Molecular Biology","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Saskatchewan","funders":"","keywords":"Proteases; Protease; IC50; Cathepsin B; Cathepsin L; Chemistry; Cathepsin; Pharmacology; Enzyme; Biochemistry; In vitro; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00002969007,0.00006853405,0.00006641083,0.00001422059,0.00007477219,0.000007003265,0.00003501128,0.00003578278,0.00003287052],"category_scores_gemma":[0.0000168675,0.00006480307,0.00002395962,0.00004351495,0.00005790495,0.000002113495,0.0001099229,0.00004434994,3.572919e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000005126353,"about_ca_system_score_gemma":0.00001306324,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001339827,"about_ca_topic_score_gemma":8.018242e-7,"domain_scores_codex":[0.999549,0.00003368205,0.00009913849,0.0001553854,0.00008322542,0.0000795946],"domain_scores_gemma":[0.999818,0.000002372484,0.0000504061,0.00008002833,0.00002082696,0.0000284173],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005283724,0.00002205908,0.0004427104,0.00001447784,0.000007290726,0.000001011011,0.00003985941,0.000002093282,0.9971498,0.00006166031,0.00138467,0.0008214925],"study_design_scores_gemma":[0.000226055,0.0001599262,0.001276405,0.000003119275,0.00000573753,0.0000166646,0.00004051105,0.00001931904,0.9898622,0.0001142435,0.008188154,0.00008766509],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9985599,0.0004797807,0.0001985277,0.0002597909,0.00002097081,0.0001029735,0.0002947692,0.000005679987,0.00007761825],"genre_scores_gemma":[0.9982478,0.00002500232,0.0001441722,0.0001567674,0.00003062757,0.00002496957,0.001153109,0.000007557089,0.0002099791],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007287638,"threshold_uncertainty_score":0.2642592,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003983467121401718,"score_gpt":0.1911006638620544,"score_spread":0.1871171967406527,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}