{"id":"W4293733615","doi":"10.3390/molecules27175552","title":"Dual Inhibition of HIV-1 and Cathepsin L Proteases by Sarcandra glabra","year":2022,"lang":"en","type":"article","venue":"Molecules","topic":"Biochemical and Structural Characterization","field":"Biochemistry, Genetics and Molecular Biology","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Saskatchewan","funders":"","keywords":"Proteases; Protease; IC50; Cathepsin B; Cathepsin L; Chemistry; Cathepsin; Pharmacology; Enzyme; Biochemistry; In vitro; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001457577,0.0005505377,0.0004730363,0.0004404767,0.000208034,0.0003407539,0.0001961651,0.0003204192,0.0008316669],"category_scores_gemma":[0.00009718905,0.0001383684,0.0005214837,0.0003217401,0.0001988952,0.0002813704,0.000214498,0.000774668,0.0002290062],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001298896,"about_ca_system_score_gemma":0.0001648654,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004260316,"about_ca_topic_score_gemma":0.001076792,"domain_scores_codex":[0.999917,0.00001694311,0.00000727948,0.00001653502,0.00002479279,0.00001740099],"domain_scores_gemma":[0.9999512,0.00000812892,0.00001514135,0.000004452922,0.00001014856,0.00001084825],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002204033,0.0001037689,0.0003065473,0.0003368029,0.00002167076,0.0001266796,0.00002685358,0.0001001964,0.9935294,0.00007528962,0.0001097032,0.005042688],"study_design_scores_gemma":[0.0001913358,0.003141569,0.0268808,0.0001811185,0.0002603954,0.00139473,0.0002000899,0.001400156,0.952126,0.0003329758,0.01385307,0.00003783706],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9817161,0.01180518,0.001929544,0.0003740748,0.00006009058,0.00006778728,0.0006777006,0.0001079836,0.003261609],"genre_scores_gemma":[0.9900165,0.00315529,0.003248708,0.0002930623,0.00002485334,0.00004404237,0.0007825847,0.00001875941,0.002416119],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008316669,"threshold_uncertainty_score":0.002782166,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003983467121401718,"score_gpt":0.1911006638620544,"score_spread":0.1871171967406527,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}