{"id":"W4293741040","doi":"10.1186/s40168-022-01337-5","title":"Lactic acid from vaginal microbiota enhances cervicovaginal epithelial barrier integrity by promoting tight junction protein expression","year":2022,"lang":"en","type":"article","venue":"Microbiome","topic":"Reproductive tract infections research","field":"Immunology and Microbiology","cited_by":112,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba","funders":"European and Developing Countries Clinical Trials Partnership; Monash Biomedicine Discovery Institute, Monash University; National Health and Medical Research Council; National Institutes of Health; Monash University; Department of Science and Technology, Ministry of Science and Technology, India; Poliomyelitis Research Foundation; Carnegie Corporation of New York; Australian Government; National Institute of Allergy and Infectious Diseases; Medical Research Council; Department of Science and Technology, Republic of South Africa; South African Medical Research Council; National Research Foundation; Burnet Institute","keywords":"Biology; Lactobacillus; Microbiology; Lactic acid; Vagina; Lactate dehydrogenase; Barrier function; Vaginal flora; Epithelium; Bacteria; Bacterial vaginosis; Enzyme; Cell biology; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","sts","insufficient_payload"],"consensus_categories":["insufficient_payload"],"category_scores_codex":[0.001191473,0.000391945,0.0004074059,0.000371427,0.001364608,0.00009719523,0.000617795,0.0002634527,0.01046336],"category_scores_gemma":[0.000159902,0.0003705179,0.0001657969,0.0006094201,0.000372897,0.0003875838,0.0005679025,0.002153554,0.00120625],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004831394,"about_ca_system_score_gemma":0.0002594112,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009872477,"about_ca_topic_score_gemma":0.00001503893,"domain_scores_codex":[0.9958616,0.00159039,0.0005303613,0.001136549,0.0001295142,0.0007515072],"domain_scores_gemma":[0.9986797,0.000108342,0.0002722925,0.0006983372,0.0001793841,0.00006195634],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004599437,0.0006605959,0.0007360316,0.00003696015,0.0001583547,0.00000868306,0.0007309087,6.783854e-7,0.9788548,0.000008917533,0.01371473,0.004629369],"study_design_scores_gemma":[0.001034064,0.0003120505,0.0007511141,0.00003864386,0.00002987499,0.0001750361,0.0003384592,0.000001475294,0.8041629,0.00007476491,0.1927532,0.000328483],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9896147,0.004258029,0.0005848288,0.0008485653,0.002171798,0.0009950997,0.00092521,0.0002212196,0.0003805668],"genre_scores_gemma":[0.9879888,0.0000122539,0.0003849354,0.00009056387,0.0002069361,0.0004158906,0.001251508,0.00005644507,0.009592609],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1790385,"threshold_uncertainty_score":0.9999355,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01208835939239461,"score_gpt":0.257811596023403,"score_spread":0.2457232366310084,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}