{"id":"W4293741040","doi":"10.1186/s40168-022-01337-5","title":"Lactic acid from vaginal microbiota enhances cervicovaginal epithelial barrier integrity by promoting tight junction protein expression","year":2022,"lang":"en","type":"article","venue":"Microbiome","topic":"Reproductive tract infections research","field":"Immunology and Microbiology","cited_by":112,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba","funders":"European and Developing Countries Clinical Trials Partnership; Monash Biomedicine Discovery Institute, Monash University; National Health and Medical Research Council; National Institutes of Health; Monash University; Department of Science and Technology, Ministry of Science and Technology, India; Poliomyelitis Research Foundation; Carnegie Corporation of New York; Australian Government; National Institute of Allergy and Infectious Diseases; Medical Research Council; Department of Science and Technology, Republic of South Africa; South African Medical Research Council; National Research Foundation; Burnet Institute","keywords":"Biology; Lactobacillus; Microbiology; Lactic acid; Vagina; Lactate dehydrogenase; Barrier function; Vaginal flora; Epithelium; Bacteria; Bacterial vaginosis; Enzyme; Cell biology; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001641136,0.0003018311,0.0002732752,0.0005262177,0.0002998693,0.0004475368,0.0001577461,0.000330641,0.004040656],"category_scores_gemma":[0.0002783851,0.0001303176,0.0003807476,0.0004864369,0.0001369598,0.0002539188,0.000340252,0.0003286072,0.0004153237],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002679537,"about_ca_system_score_gemma":0.0003112582,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002445317,"about_ca_topic_score_gemma":0.003784025,"domain_scores_codex":[0.999882,0.0000177104,0.000004198149,0.00003134208,0.00003686205,0.00002798081],"domain_scores_gemma":[0.9999183,0.00001828344,0.00002737532,0.000004247368,0.00001862579,0.00001310219],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005415031,0.00003979927,0.02114595,0.0006999863,0.0001071639,0.0001653319,0.0001080826,0.0001665025,0.9550355,0.0001070176,0.001018087,0.02086514],"study_design_scores_gemma":[0.0000465198,0.0009282309,0.5929095,0.0003584289,0.0003525466,0.0007335499,0.0009347129,0.002665881,0.3783662,0.0006169932,0.02205108,0.00003632202],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9593958,0.01400461,0.005988454,0.0007316911,0.0001641468,0.0001351091,0.01449813,0.000168287,0.004913771],"genre_scores_gemma":[0.9705932,0.008031365,0.008505624,0.0004075234,0.00005959997,0.0001171216,0.007702176,0.00004642646,0.004537029],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004040656,"threshold_uncertainty_score":0.01351732,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01208835939239461,"score_gpt":0.257811596023403,"score_spread":0.2457232366310084,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}