{"id":"W4293755562","doi":"10.1186/s12943-022-01640-7","title":"PDGFRβ promotes oncogenic progression via STAT3/STAT5 hyperactivation in anaplastic large cell lymphoma","year":2022,"lang":"en","type":"article","venue":"Molecular Cancer","topic":"Lymphoma Diagnosis and Treatment","field":"Medicine","cited_by":34,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"National Cancer Institute","keywords":"Cancer research; Anaplastic large-cell lymphoma; Biology; STAT3; Platelet-derived growth factor receptor; STAT5; Growth factor receptor; Signal transduction; Growth factor; Lymphoma; Immunology; Receptor; Cell biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000088104,0.0001551373,0.0001170037,0.0001648063,0.0001115043,0.0002233037,0.00007820815,0.0001255649,0.001326784],"category_scores_gemma":[0.00004463125,0.00007900225,0.0001567531,0.00009387032,0.0001159078,0.00007549099,0.00009449496,0.0003086345,0.0002859306],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00021044,"about_ca_system_score_gemma":0.0001547793,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004676348,"about_ca_topic_score_gemma":0.0006865966,"domain_scores_codex":[0.9999341,0.00001188071,0.000005219993,0.0000102758,0.00001828908,0.00002025428],"domain_scores_gemma":[0.9999722,0.000003643155,0.000008344714,0.000002516592,0.000002658958,0.00001066376],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002645318,0.00005809717,0.001160398,0.00003704818,0.000008081667,0.0001595962,0.00001119301,0.0001361552,0.9951345,0.0001479277,0.0001608597,0.00272155],"study_design_scores_gemma":[0.0001505297,0.001170547,0.03785668,0.0000175532,0.00007780666,0.001814153,0.00007988534,0.003803529,0.9470422,0.0003344942,0.007644464,0.000008241036],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9945565,0.001866378,0.001342954,0.0001299579,0.00002533717,0.00001582772,0.0002551285,0.0001165111,0.001691437],"genre_scores_gemma":[0.9986627,0.0003861386,0.0002350579,0.00003865145,0.000004503474,0.000007736663,0.0001176176,0.000003516127,0.0005440747],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001326784,"threshold_uncertainty_score":0.00443846,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008495873797131988,"score_gpt":0.2833116882356187,"score_spread":0.2748158144384867,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}