{"id":"W4293755562","doi":"10.1186/s12943-022-01640-7","title":"PDGFRβ promotes oncogenic progression via STAT3/STAT5 hyperactivation in anaplastic large cell lymphoma","year":2022,"lang":"en","type":"article","venue":"Molecular Cancer","topic":"Lymphoma Diagnosis and Treatment","field":"Medicine","cited_by":34,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"National Cancer Institute","keywords":"Cancer research; Anaplastic large-cell lymphoma; Biology; STAT3; Platelet-derived growth factor receptor; STAT5; Growth factor receptor; Signal transduction; Growth factor; Lymphoma; Immunology; Receptor; Cell biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001102583,0.0001748967,0.0002399151,0.0001442989,0.000124952,0.00001531595,0.00006673837,0.00004224075,0.0005198782],"category_scores_gemma":[0.00001851786,0.0001551516,0.00009039666,0.0003700892,0.00001662428,0.00006541675,0.00009068576,0.0000968198,0.0000181231],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001286093,"about_ca_system_score_gemma":0.0003910577,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002879336,"about_ca_topic_score_gemma":0.00005951299,"domain_scores_codex":[0.9985262,0.00009092859,0.0002252004,0.0003662444,0.0004545821,0.0003368793],"domain_scores_gemma":[0.9994846,0.00003222597,0.0001019669,0.0002340274,0.00004580883,0.000101344],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002604581,0.02296162,0.3095679,0.0004508273,0.0004443359,0.007774705,0.002364979,0.001011493,0.3485703,0.0002229675,0.003118395,0.3009079],"study_design_scores_gemma":[0.04391095,0.003921168,0.2558432,0.0003727097,0.0004971412,0.000223919,0.0005733055,0.00689448,0.6195846,0.0002235293,0.06710459,0.000850404],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9945508,0.002990982,0.0001861758,0.0006872158,0.0001690061,0.0008058002,0.0000493281,0.00004296223,0.0005177386],"genre_scores_gemma":[0.9972503,0.00007884317,0.0003103658,0.000661985,0.00003443711,0.001265761,0.0001584006,0.00003791683,0.0002020349],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3000575,"threshold_uncertainty_score":0.6326898,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008495873797131988,"score_gpt":0.2833116882356187,"score_spread":0.2748158144384867,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}